Study On The Correlation Between Serum Thyroid Hormone In The Normal Range Of Patients With Type 2 Diabetes And Sarcopenia

Objective To explore the influence of the reduction of serum thyroid hormone levels in the normal range of patients with type 2 diabetes mellitus（T2DM）on the related indicators of sarcopenia.Methods A total of 192 T2 DM patients（105 males and 87 females）with the thyroid hormone levels in the normal range between 40 and 70 years old in the First Affiliated Hospital of Anhui Medical University from April 2020 to November 2020 were enrolled.General data of the patients were collected.Blood glucose,blood lipids,thyroid function,bioelectrical impedance analysis（BIA）is used to measure appendicular skeletal muscle,dynamometer hand grips to measure handgrip strength,SPPB to measure physical performance,and to analyze the relationship between thyroid stimulating hormone（TSH）,thyroxine（T4）,triiodothyronine（T3）,free thyroxine（FT4）,free triiodothyronine（FT3）and related indicators of sarcopenia.Results The prevalence rate of sarcopenia was 6.25%.Age was negatively correlated with appendicular skeletal muscle mass（ASM）,appendicular skeletal muscle mass index（ASMI）,and the score of short physical performance battery（SPPB）.Gender was negatively correlated with ASM and ASMI.,Handgrip strength was positively correlated,T3 was negatively correlated with the score of SPPB（β=-0.324,P=0.047）,T4 was negatively correlated with ASMI,ASM,and TSH was negatively correlated with handgrip strength（β=-0.133,P=0.032）.Conclusions In patients with T2 DM,thyroid function is related to muscle-related indicators.Clinical attention should be paid to the thyroid function of patients with T2 DM,which is helpful for early identification and screening of individuals.