Associations Between Serum Thyrotropin Level And Glycosylated Hemoglobin In Non-diabetic Population In Guiyang City

Objective: In recent years,there are still some differences in the results of many studies on the correlation between TSH and Hb A1 c.The purpose of this study was to investigate the relationship between serum TSH and Hb A1 c in non-diabetic population in guiyang.Methods: From May to October 2011,a total of10,140 residents aged 40 and above who had lived in the community for 5 years or more were selected by cluster sampling method in yunyan district,guiyang city,guizhou province,and 5,819 residents were eventually included for observation.All subjects were subjected to detailed epidemiological questionnaires,basic information was collected,height and weight were measured and body mass index(BMI)was calculated,waist circumference and blood pressure were measured,and blood was sent to the laboratory for blood glucose,blood lipid,insulin,Hb A1 c and TSH.According to TSH level,the population was divided into the normal TSH group and the elevated TSH group.T test,non parameter test and logistic regression analysis were used.Results: There were 4 632 patients in the normal TSH group and 1 187 patients in the elevated TSH group.Compared with the normal TSH group,the Hb A1 c value of the elevated TSH group was lower(P<0.05),while the BMI,FINS,HOMA?IR,TG,LDL?C and TC were higher,with statistically significant differences(P< 0.05).After adjusting for age,gender,systolic pressure,diastolic pressure,BMI,waist circumference,FPG,OGTT 2 h blood glucose,FINS,HOMA?IR,TG,Hb A1 c,LDL?C,logistic regression analysis results showed that compared with the normal TSH group,the elevated TSH group was the factor affecting Hb A1 c.TSH was negatively correlated with Hb A1c(OR=0.845,P= 0.024,95%CI=0.730 to0.978).After further gender stratification,the negative correlation between TSH and Hb A1 c was found only in males(OR=0.672,P=0.034,95% CI=0.466 to 0.970),but not in females.Body type stratification was conducted according to BMI.TSH in people of normal weight was an independent factor affecting Hb A1 c,and the two were negatively correlated(OR=0.766,P=0.012,and the 95% confidence interval was0.622 to 0.944).There was no significant correlation between TSH and Hb A1 c in people who were underweight,overweight or obese.Conclusion: In people without diabetes,increased TSH may reduce Hb A1 c.There was a negative correlation between serum TSH and Hb A1 c in male non-diabetic population and no significant correlation between serum TSH and Hb A1 c in female non-diabetic population.There was a negative correlation between TSH and Hb A1 c in people of normal weight,while there was no significant correlation between TSH and Hb A1 c in people of low weight,overweight and obese.