Correlation Analysis Between Serum Uric Acid Level And Retinopathy In Patients With Type 2 Diabetes Mellitus

Objective: To investigate whether serum uric acid（SUA,serum cicacid）is associated with the occurrence of diabetic retinopathy（DR,diabetic retinopathy）in patients with type 2 diabetes mellitus（T2DM,type 2 diabetes mellitus）.Methods: A retrospective study was conducted on 2359 patients with T2 DM who were hospitalized in the Department of Endocrinology,Genetics and Metabolism,Affiliated Hospital of Jining Medical College from July 1,2017 to April 30,2021.The clinical baseline data of the study population were obtained through the electronic medical record system,including gender,age,course of DM,past chronic disease history,etc.;the patient’s weight,height and other measurement data were obtained through physical examination,and the body mass index was calculated;laboratory test indicators included blood routine,liver Work,renal function,blood lipids,fasting blood glucose,glycosylated hemoglobin,urine microalbumin,etc.All patients were screened for fundus lesions by an ophthalmologist,and the patients were divided into DR group and non-DR（NDR,non-diabetic retinopathy）group according to the results of fundus photography.analyze.Results: A total of 2359 patients with T2 DM were included in this study,including 1093 women and 1266 men.The mean age of all T2 DM patients included was（54.7±12.0）years.There were 709 T2 DM patients in the DR group,accounting for 30.06% of the total population;1650patients in the NDR group,accounting for 69.94% of the total population.In this study,there were 217 patients with HUA,including 115 males and102 females,and the overall prevalence of HUA was 9.00%.The results of the univariate analysis module showed that the course of DM,age,hypertension,coronary heart disease,anemia,serum creatinine,serum uric acid,and urine microalbumin were positively correlated with the risk of DR（P<0.05）.Diastolic blood pressure,triglyceride,total bilirubin,and indirect bilirubin were negatively correlated with the risk of DR（P<0.05）.Systolic blood pressure,BMI,total cholesterol,high-density lipoprotein cholesterol,and low-density lipoprotein cholesterol,direct bilirubin,fasting blood glucose,glycosylated hemoglobin had no significant correlation with the occurrence of DR（P>0.05）.The smooth curve fitting part adjusts confounding factors such as DM duration,age,hypertension,coronary heart disease,diastolic blood pressure,anemia,total bilirubin,indirect bilirubin,triglyceride,serum creatinine,and urine microalbumin.Afterwards,the level of SUA and the risk of DR in both male and female T2 DM patients showed a straight line,that is,a positive correlation（P<0.05）.The study population was stratified by gender,and the threshold effect analysis partially showed that in male T2 DM patients,there was a significant After adjusting for confounding factors such as erythromycin,fasting blood glucose,glycosylated hemoglobin,serum creatinine,and urinary microalbumin,it was found that in male T2 DM patients,SUA was positively correlated with the risk of DR（P<0.05）.Conclusion: This study shows that in T2 DM patients,SUA level is one of the risk factors for DR in T2 DM patients.And there are gender differences in the level of SUA and the occurrence of DR.In male T2 DM patients,there is a positive correlation between SUA and the risk of DR.