| Objective: To investigate the relationship between AECOPD and periodontitis by comparing the periodontal status,pulmonary function status and serum PCT level between patients with acute exacerbation of COPD and patients with stable COPD.Methods: 90 patients with chronic obstructive pulmonary disease(COPD)were selected as the study subjects,including 46 patients with acute exacerbation COPD and 44 patients with stable phase.According to the degree of mild,moderate and severe periodontitis,the patients were divided into 8 groups: 4 cases of AECOPD with periodontitis stage I(group A),23 cases of AECOPD with periodontitis stage II(group B),10 cases of AECOPD with periodontitis stage III(group C),and 9 cases of AECOPD with periodontitis stage IV(group D).COPD stable stage with stage I periodontitis(group E)9 cases,COPD stable stage with stage II periodontitis(group F)26cases,COPD stable stage with stage III periodontitis(group G)6 cases,COPD stable stage with stage IV periodontitis(group H)3 cases;Age,gender,body mass index(BMI),smoking history,pulmonary function indicators: the percentage of forced vital capacity in1 s expiratory volume(FEV1/FVC%),the percentage of forced expiratory volume in 1s expected value(FEV1%pred),and periodontal clinical indicators were recorded: Pocket probing depth(PPD),Clinical attachment loss(CAL),Plaque index(PLI),Community periodontal index(CPI),sulcus bleeding index(SBI),serum Procalcitonin(PBI),Plaque index(PLI),Plaque index(PLI),Plaque index(PLI),Community periodontal index(CPI),sulcus bleeding index(SBI),serum Procalcitonin(PBI),Plaque index(PLI),Plaque index(PLI),Plaque index(PLI),Plaque index(PLI),Plaque index(PLI),Plaque index(PLI)and Plaque index(PLI).PCT level,and the relevant data of each group were statistically analyzed.RESULTS: The age,gender,BMI and smoking status of the patients were not statistically significant(P>0.05).The proportion of severe periodontitis in patients with AECOPD was significantly higher than that in patients with stable periodontitis(P<0.05).PPD and SBI in group A were significantly higher than those in group E.PPD and CAL in group B were significantly higher than those in group F.SBI and Cal in group C were significantly higher than those in group G,PLI in group D was significantly higher than those in group H(P < 0.05).FEV1/FVC% FEV1%pred in AECOPD group decreased with the increase of the severity of periodontitis(P<0.01).FEV1/FVC% FEV1%pred decreased with the increase of the severity of periodontitis in stable stage group(P<0.01).The serum PCT level in AECOPD stage group was significantly higher than that in stable stage group(P<0.01),the serum PCT level in different periodontal stages.The serum PCT level was positively correlated with PPD(r=0.60,P<0.01).The serum PCT level was positively correlated with CAL(r=0.58,P<0.01).Serum PCT level was positively correlated with SBI(r=0.31,P= 0.03).The serum PCT level was negatively correlated with FEV1/FVC%(r=-0.79,P<0.01).There was a significant negative correlation between serum PCT level and FEV1%pred(r=-0.802,P<0.01).There was a positive correlation between community periodontal index CPI and serum PCT level in AECOPD group(r=0.511,P<0.01).There was a positive correlation between the community periodontal index CPI and serum PCT level in the stable stage group(r=0.474,P < 0.01).Conclusion: Results of this study suggests that the severity of periodontitis may have a mutual promoting effect with the development of COPD,Serum PCT may reflect the severity of periodontitis and the risk of acute exacerbation in COPD patients to a certain extent. |
