Shenxi Capsule Combined With Methimazole Treatment Clinical Observation Of Qi Deficiency And Blood Stasis Syndrome In Hyperthyroidism (Graves Disease)

Objective:through the theoretical study of hyperthyroidism,from the pathogenesis,treatment and other aspects of the current Chinese medicine to the understanding of hyperthyroidism.Ginseng and capsules on joint a sulfhydryl imidazole Graves disease patients with qi deficiency blood stasis before and after treatment in the thyroid volume and thyroid hormone levels(FT3,FT4,TSH),antibody levels(TRAB,TPOAB,TGAB),hemorheology index(whole blood viscosity,plasma viscosity,erythrocyte volume and erythrocyte aggregation index),the change of the respect such as clinical symptoms;To evaluate the safety and effectiveness of Shenxi capsule combined with methimazole in the treatment of Graves’ disease with qi deficiency and blood stasis syndrome。Methods:60 patients who are illed with Graves’ disease syndrome of qi deficiency and blood stasis were randomly divided into two groups by SPASS software,with 30 patients in the treatment group and 30 in the control group.To into the study of the subjects were given basical treatment,the control group given only to single-agent a sulfhydryl imidazole treatment,treatment group use the cords and capsule combined a sulfhydryl imidazole treatment,after a period of intervention for 3 months,two groups were compared in thyroid hormone levels,antibody levels,hemorheology indices,body weight,heart rate and TCM symptoms integral,clinical symptoms,blood in urine routine,electrocardiogram,liver and kidney function changes after treatment.Results:(1)General situation:two groups had no distinction in age、course of disease、gender,laboratory indicators and TCM symptom scores before the treatment(P>0.05).(2)Clinical efficacy:The treatment group’s effective rate was 96.67%,while in the control group that was only 73.33%;There were significant differences between the two groups(P<0.05),whitch indicated that the clinical efficacy of Shenxi capsule combined with methimazole was much better than the another one.(3)TCM syndrome scores:the TCM syndrome score in the treatment group was significantly lower than that in the control group(P<0.01),indicating the improvement of clinical efficacy in the treatment group was better than that in the control group.(4)Thyroid hormone levels:there was no statistical difference in thyroid hormone levels between the two groups before treatment(P>0.05),which was comparable.FT3 and FT4 levels in 2 groups after treatment were lower than before treatment,while TSH level in 2 groups after treatment was higher than before treatment,with statistical significance(P<0.05).Comparison between groups showed that after treatment,FT3 and FT4 levels in the treatment group were lower while TSH levels were higher than those in the control group(P<0.05).(5)Comparison of the levels of autoantibodies:there was no statistical significance in the levels of thyroid-related antibodies between the two groups before treatment(P>0.05),which was comparable.The levels of TRAb,TPOAb and TgAb in 2 groups after treatment were lower than before treatment,with statistical significance(P<0.05).After treatment,the levels of TRAb,TPOAb and TGAb in the treatment group were lower than those in the control group,which was significant(P<0.05).(6)Thyroid ultrasound suggested that:before treatment,left lobe volume,right lobe volume and isthmus thickness were compared between the two groups,and the differences were not statistically significant(P>0.05),which showed comparability.The volume of left lobe and right lobe in 2 groups decreased,and the thickness of isthmus in the treatment group decreased more significantly after treatment.Thyroid volume in the treatment group were lower than those in the control group(P<0.05).(7)Intra-group comparison showed that the whole blood viscosity,plasma viscosity and erythrocyte aggregation index of 2 groups after treatment were significantly lower than before,After treatment,the treatment group were significantly lower in the whole blood viscosity and plasma viscosity compared with control group(P<0.05).(8)Safety indicators:There were no adverse reactions in patients of the two groups,such as nausea and vomiting,allergy,hair loss,and there were no abnormalities in three routine tests,ECG,liver and kidney function,etc.Research conclusions:this study suggests that,ginseng capsule combined a sulfhydryl imidazole Graves disease recovery qi deficiency blood stasis with obvious therapeutic effect,not only can obviously improve the patient’s thyroid function and reduce the degree of thyroid antibody level,and still can reduce the body state of high pour-point and high adhesion,effectively improve the clinical symptoms and signs.The drug is of high security and worthy of further popularization in clinical.