| Objective:To investigate the correlation between fatty acids and visceral fat in patients with type 2 diabetes mellitus(T2DM),and to further analyze the relationship between various fatty acid components and anthropometric indexes,clinical biochemical indexes and insulin sensitivity.To find the significance of fatty acid biomarkers for insulin resistance and lipid metabolism disorder.Methods:A cross-sectional study was conducted to collect 443 patients with type 2diabetes patients from November 2018 to December 2019 in the endocrinology department of the second affiliated hospital of Dalian Medical University,according to the internationally accepted criteria for diagnosis and classification of the WHO(World Health Organization)expert Committee on Diabetes(1999).First,record general data of patients in the group:sex,age,height,weight,BMI.Then,the serum levels of the fasting blood glucose,glycosylated hemoglobin,fasting insulin,blood lipids(total cholesterol,total triglyceride,low density lipoprotein,high density lipoprotein)and insulin resistance in venous blood collected from patients at an empty stomach for 8 hours in the morning were detected,at the same time collect data of fatty acid metabolism spectrum(Myristic acid,myristic acid,palmitic acid,palmitoleic acid,docosapentaenoic acid,linolenic acid,docosatetraenoic acid,linoleic acid,oleic acid,stearic acid,eicosapentaenoic acid,docosahexaenoic acid,eicosatrienoic acid,arachidonic acid,arachidic acid,eicosenoic acid,eicosadienoic acid,total omega-3,total omega-6,omega-3/omega-6,triene/tetraene,total fatty acid,total monounsaturated fatty acid,total polyunsaturated fatty acid,total saturated fatty acid).According to the visceral fat classification criteria,the T2DM patients were divided into three groups:normal visceral fat group(group A):VFA<100cm~2,n=198;high visceral fat group(group B):100≤VFA<150 cm~2,n=62;higher visceral fat group(group C):VFA≥150cm~2,n=62.The differences and correlation of fatty acid metabolism spectrum and related metabolic indexes among the three groups were compared.Results:Compared with the normal visceral fat group(group A),the body weight,BMI,visceral fat,subcutaneous fat,fasting insulin,insulin resistance,myristic acid,palmitoleic acid,palmitic acid,eicosatrienoic acid,total saturated fatty acids and total monounsaturated fatty acids were higher and the level of HDL-c were lower in the high visceral fat group(group B)and higher visceral fat group(group C).The level of TG in high visceral fat group(group B)was increased,The levels of fasting blood glucose and docosatetraenoic acid were increased in higher visceral fat group(group C).Spearman correlation analysis showed that the levels of palmitic acid,myristic acid,palmitic acid,eicosatrienoic acid and total saturated fatty acids were positively correlated with TC,TG,visceral fat,fasting blood glucose and insulin resistance,but negatively correlated with HDL-c(P<0.05),The results of multiple regression analysis showed that weight,TG,LDL-c,subcutaneous fat and HDL-c were the influencing factors of serum palmitic acid level,all were statistically significant(P<0.05).Conclusions:There is a disorder of fatty acid metabolism in patients with type 2diabetes mellitus and abdominal obesity,in which the concentration of saturated fatty acids is increased(represented by palmitic acid and myristic acid).It is disadvantageous to insulin resistance,isletβ-cell function,blood glucose and blood lipid profile.High levels of serum palmitic acid,myristic acid,palmitic acid,eicosatrienoic acid and total saturated fatty acids may be involved in glucose and lipid metabolism disorders and abdominal visceral fat accumulation.While actively correcting the disorder of glucose and lipid metabolism,we should appropriately reduce the intake of corresponding fatty acids in the diet,which may play a positive role in reducing the accumulation of visceral fat in the abdominal cavity,and provide a new possibility for the combined prevention and treatment of T2DM and abdominal obesity. |
PDF Full Text Request