| 【Objectives】To observe and analyze the high frequency ultrasound(HFUS)manifestations and related complications of gouty arthritis(GA)of the knee,and to further explore the relationship between the above ultrasonic manifestations and related complications of GA and the level of blood uric acid and course of disease,as well as the relationship between the bone erosion of knee joint and synovitis and the formation of gout nodule were further investigated.【Methods】A total of 102 patients with knee joint GA clinically diagnosed in our hospital from November 2018 to December 2020 were collected,including 95 male patients and 7female patients.The average age was 50.86±14.14 years old from 20 to 80 years old.There were 27 cases of bilateral knee joint involvement and 75 cases of unilateral knee joint involvement,a total of 129 knee joint lesions.All patients’ knee joints were examined by HFUS,and the incidence of joint cavity effusion,synovial hyperplasia,intrasynovial blood flow signal,"snowstorm sign","double-track sign",gout nodules and bone erosion were observed and calculated.The incidence rates of related complications(including hypertension,hyperlipidemia,abnormal glucose metabolism,fatty liver,kidney stones,carotid atherosclerosis,etc.)were collected and calculated.χ2test and Spearman correlation test were used to analyze the data statistically.【Resuits】1 There was significant correlation between serum uric acid level and synovial hyperplasia,intrasynovial blood flow signal,"dual-track sign" and count of gout nodule(P<0.05),but no significant correlation with joint effusion,"blizzard sign" and count of bone erosion(P>0.05).There was significant correlation between the course of disease and the count of "double track sign",gout nodule and bone erosion(P<0.05),but no significant correlation with the count of joint effusion,synovial hyperplasia,intrasynovial blood flow signal and "blizzard sign"(P>0.05).2 There was statistically significant difference in gout nodules between the osteoerosion group and the non-osteoerosion group(χ2=41.857,P<0.01).There was no statistically significant difference in synovitis between the two groups(χ2=0,P=1.000).3 There was significant correlation between serum uric acid level and knee joint GA combined with hypertension,fatty liver,kidney stones and carotid atherosclerosis count(P<0.05),but no significant correlation with hyperlipidemia and abnormal glucose metabolism count(P>0.05).There was a significant correlation between the course of disease and the number of knee joint GA combined with the above complications(P<0.05).【Conclusions】1 The level of blood uric acid was significantly positively correlated with synovial hyperplasia,intrasynovial blood flow signals and the "dual-track sign" in GA patients.The course of gout was positively correlated with the occurrence of "double track sign",gout nodules and bone erosion.2 The HFUS manifestations of knee GA are both universal and particularity:Gout nodule formation in the knee may aggravate the level of bone erosion.3 In this study group,knee GA complicated with hypertension,fatty liver,kidney stones and carotid atherosclerosis were positively correlated with blood uric acid level and course of disease;knee GA complicated with hyperlipidemia and abnormal glucose metabolism were positively correlated with the course of disease. |
