| Objective:Through the analysis of the imaging data,clinical symptoms,corresponding surgical methods and postoperative histopathological characteristics of intracranial chondrosarcoma,the general status and progress of diagnosis and treatment were summarized.The diagnosis and treatment ability of intracranial chondrosarcoma has been further improved.Methods:From January 2010 to December 2020,15 cases of intracranial space occupying chondrosarcoma were collected.By searching Pub Med,Science Direct and other databases,40 cases of retrospective literature were obtained.The case entry criteria were: through surgical treatment,postoperative histopathology consistent with chondrosarcoma cases,excluding intracranial chordoma and other types of metastases.The clinical manifestations,imaging and postoperative pathological features,immunohistochemical features and corresponding prognosis of all cases were analyzed retrospectively.Results:All of the 15 patients and 40 cases(including 2 cases of endoscopic tumor resection by nasal transsphenoidal approach)in the first hospital of Jilin University underwent surgical intervention to remove the tumor.There were 21 patients treated with surgery alone and 34 patients treated with postoperative adjuvant chemotherapy(27patients treated with radiotherapy alone,3 patients treated with chemotherapy alone and 4 patients treated with radiotherapy combined with chemotherapy).The first operation was total resection in 34 cases,subtotal resection in 14 cases and undescribed resection degree in 7 cases.A total of 55 patients were collected,45 of them were described the follow-up results.Up to January 2021,12 patients in the first hospital of Jilin University obtained the follow-up results through telephone and outpatient reexamination.33 patients in the literature had prognosis description.The average follow-up time of all patients was 25.2 months.The follow-up records were obtained.Among the 45 cases,17 cases were treated only by operation,6 cases were recurred(about 35.3%),3 cases died(about17.6%),and the average survival time was 25.1 months.The prognosis of 28 cases with postoperative adjuvant therapy was described,including 7 cases of recurrence(about 25%),3 cases of death(about10.7%),and the average survival time was 25.3 months.40 cases were followed up.The prognosis of 29 cases with total resection was described,including 7 cases of recurrence(24.1%),2 cases of death(6.9%),and the average survival time was 26.1 months.Subtotal resection was performed in 11 cases,3 cases recurred(27.2%);3cases died(27.2%);the average survival time was 25.6 months.After total tumor resection and postoperative radiotherapy,the proportion of patients with recurrence or death is low.The average survival time was longer than that of subtotal resection,surgery and chemotherapy.Compared with other types of chondrosarcoma,mesenchymal chondrosarcoma has shorter survival time and poorer prognosis.Conclusion:1.The non-specific clinical manifestations and imaging features of intracranial chondrosarcoma make the preoperative diagnosis difficult to a certain extent.The diagnosis can be made by combining the intraoperative findings with pathological examination2.The survival time of mesenchymal chondrosarcoma is shorter than other types of intracranial chondrosarcoma.3.Postoperative adjuvant radiotherapy may improve the prognosis to some extent. |
