Effect Of Sodium Metabolism In Vivo After Operation Of Space Occupying Lesions In Saddle Region

Background and objective:In order to strengthen the understanding of the disorder of water and sodium metabolism before and after the operation of space occupying lesions in saddle region,guide the clinical treatment,improve the prognosis of patients,and explore the influencing factors of sodium metabolism disorder,so as to provide a theoretical basis for the clinical prevention of sodium metabolism disorder in patients with space occupying lesions in saddle region.Materials and Methods:This paper retrospectively analyzed and summarized the clinical data and postoperative follow-up data of 292 patients with saddle occupying lesions treated by micro-neurosurgery in the Neurosurgery Department of Shandong Provincial Hospital from March 2018 to March 2021.Among them,292 patients were admitted from March 2018 to March 2021,including 133 males and 159 females.The male to female ratio was 1:1.19,and the age ranged from 5 to 72(45.84± 17.24)years old.The relationship between serum sodium level and pathological types,location,size,surgical methods,treatment methods,clinical outcomes at discharge(death,disturbance of consciousness and wakefulness)of space occupying lesions in saddle region were analyzed,and the influencing factors of sodium metabolism disorders were analyzed.Results:In this group of patients,there were 268 cases,95 cases of sodium metabolism disorder after operation,the incidence was 35.45%.According to the KPS score at discharge,255 patients had good prognosis,8 were good,3 were inferior,1 was good,2 were critical and 1 was dead.The incidence of hypernatremia was significantly different in different tumor types and different surgical methods after space occupying lesions in saddle region.(P<0.05).Conclusion:1.Sodium metabolism disorder is one of the common postoperative complications of space-occupying lesions in saddle region,and the incidence of postoperative hyponatremia is higher than that of postoperative hypernatremia.2.Different surgical methods have a significant impact on the occurrence of postoperative hypernatremia in space occupying lesions in the sellar region,and the incidence of postoperative hypernatremia is higher when the operation method of transcranial approach is chosen.3.Different tumor types have significant influence on the occurrence of hypernatremia after space occupying lesions in sellar region,among which craniopharyngioma has more hypernatremia after surgery.