Effect Of Obesity On The Prognosis Of Common Female Hormone-related Cancers

Objective:To explore the effect of obesity on the prognostic characteristics of three common hormone-related cancers in women,including breast cancer,ovarian cancer and endometrial cancer.Methods:The medical records of female patients with breast cancer,ovarian cancer and endometrial cancer admitted to our hospital from January2017 to December 2017 were retrospectively analyzed.A total of 206 cases were included,including 102 cases of breast cancer,53 cases of ovarian cancer,and 51 cases of endometrial cancer.The patients with breast cancer,ovarian cancer,and endometrial cancer were divided into obese group（BMI）≥28kg/m²and non-obese group,BMI<28 kg/m².Analysis of age,height,weight,BMI,menopausal status,clinicopathological characteristics（including TNM stage or FIGO stage of tumor,pathological type of tumor,etc.）,treatment methods,follow-up data（including viable state,survival state,disease-free survival period）between obese and non-obese groups are there statistical significance.In addition,the difference of hormone receptor（HR）,human epidermal growth factor receptor-2（HER-2）status,cell proliferation nuclear antigen（Ki-67）,and molecular typing between two groups of breast cancer patients were analyzed to find whether they were statistically significant or not.SPSS22.0 software was used to analyze the two sets of data.The measurement data was expressed as mean±standard deviation（（?）±s）,and the data comparison between groups was analysed by t test.The count data was expressed by the rate（%）,and the data comparison between the groups was analysed byx²test;disease-free survival curve was drawn by Kalan-Meier method.Take the inspection levelα=0.05,and the basis for the difference being statistically significant is P<0.05.Results:1.In the 102 breast cancer patients,39 were in the obese group with an average age of 52.15±10.81 years;63 were in the non-obese group with an average age of 50.51±8.48 years.There was no statistically significant difference between the two groups in the age at diagnosis,the menopausal status at the time of diagnosis and the diseased location（P>0.05）.In terms of tumor TNM stage,the proportions of T₁（30.3%）,N₀（50.8%）and M₀（95.2%）in the non-obese group were higher than those in the obese group,while T₃（28.0%）and M₁（23.1%）in the obese group,the incidence was significantly higher than that in the non-obese group,and the differences were statistically significant（P<0.05）.In terms of tumor pathological staging,there was no statistically significant difference between the two groups of patients in stages 0-I,II,and III（P>0.05）.The proportion of stage Ⅳ in the obese group was significantly higher than that in the non-obese group,and the difference was statistically significant（P<0.05）.There was no significant difference in pathological type,HR,HER-2,Ki-67,molecular typing,treatment,survival status,survival status,and disease-free survival between the obese group and the non-obese group（P>0.05）.2.In the 53 ovarian cancer patients,18 were in the obese group with an average age of 52.13±3.71 years;35 were in the non-obese group with an average age of 51.30±11.32 years.There was no significant difference in age and menopausal status at the time of diagnosis between the two groups（P>0.05）.In terms of FIGO staging of tumors,the obese group was dominated by stage Ⅳ（44.5%）.The proportion was significantly higher than that of the non-obese group,and the proportion of group I stage（14.3%）in non-obese was significantly higher than that of the obese group.The differences were statistically Significant（P<0.05）.The two groups of patients had no significant statistical differences in pathological types,treatment methods,survival status,survival status,and disease-free survival（P>0.05）.3.In the 51 endometrial cancer patients,20 were in the obese group with an average age of 53.20±6.19 years old;31 were in the non-obese group with an average age of 55.61±6.72 years old;there was no significant statistical difference in age composition and menopausal status between the two groups of patients（P>0.05）.In terms of FIGO staging of tumors,the obese group was dominated by stage I（70.0%）,the difference was statistically significant（P<0.05）;While the difference between the two groups of patients in stages II,III,and Ⅳ was not statistically significant（P>0.05）.The two groups of patients had no significant statistical differences in pathological types,treatment methods,survival status,survival status,and disease-free survival（P>0.05）.Conclusion:Although obesity can affect the risk of breast cancer,ovarian cancer and endometrial cancer through hormones such as estrogen,but obesity has different effects on the prognostic characteristics of women with these three hormone-related cancers:1.obese patients with breast and ovarian cancer have a higher degree of malignancy;2.obese patients with endometrial cancer have relatively better biological characteristics.