Comparative Study On Synchronous Primary Endometrial And Ovarian Carcinomas With Primary Endometrial Cancer With Ovarian Metastasis

Objective :Comparative Study on synchronous primary endometrial and ovarian carcinomas with primary endometrial cancer with ovarian metastasis. Analysis the general condition, Clinical features, the pathologic result, treat, the prognosis of the two diease. Better to guide clinical work. Methods:Choose from January 2000 to January 2015 in Shanxi Province tumor hospital was diagnosed with endometrial and ovarian carcinomas of clinical and pathological data of 52 patients, 24 patients with synchronous primary endometrial and ovarian carcinomas,27 patients with primary endometrial cancer with ovarian metastasis. Endometrial ovarian cancer metastasis in 1 case, because of its less cases, did not participate in case study. For the statistical analysis by SPSS 16.0, if two groups of cases > 40,we adopted four tables of x2 test results. When two groups of cases < 40, the calculation results by Fisher’s exact probability method. Measurement data using t test between the two groups. Inspection level of alpha = 0.05. Results:Primary double cancer groups’ average age was 46.63±7.552, metastatic carcinoma group of average age was 52.82± 9.549. Comparison between the two way(t = 2.564, P = 2.564) was statistically significant(P < 0.05). Primary double carcinoma group of younger, most of the patients not menopause, and metastatic carcinoma group of older patients, most postmenopausal. Through 24 cases of primary double cancer group and 27 cases of metastatic carcinoma the comparison of two groups of symptoms start, comparison between the two groups was statistically significant(P < 0.05). Group of the first symptoms of patients with primary double carcinoma with pelvic mass and abdominal pain more, and metastatic carcinoma group of patients with irregular vaginal bleeding and attendance of more. Through the primary double cancer group and 22 cases of metastatic carcinoma in the group of 14 cases of myometrium invasion depth contrast, Will ≤1/3(shallow layer) and 1/3-1/2 and>1/2(deep muscularis) comparison, comparison between the two groups was statistically significant(P < 0.05). Patients with primary double carcinoma group myometrium invasion depth is shallow, mostly and metastatic carcinoma group of patients with uterine deep embellish into more. Through 24 cases of primary double cancer group and 27 cases of metastatic carcinoma of the existence of ascites, comparison between the two groups was statistically significant(P < 0.05), Primary double presence of ascites carcinoma group is less, and more metastatic carcinoma group. Based on the primary double group and metastatic carcinoma of endometrium cancer differentiation degree of comparison, comparison between the two groups was statistically significant(P < 0.05). Primary double degree of endometrial differentiation carcinoma group is better than that of metastatic carcinoma group. Through 24 cases of primary double cancer group and 27 cases of metastatic carcinoma vascular tumor emboli infringement case comparison, comparison between the two groups was statistically significant(P < 0.05). Most primary double carcinoma group did not see vascular tumor emboli, and metastatic carcinoma group more. Primary double in two cases of patients with no lymph node cleaning, Through 22 cases of primary double cancer group and 27 cases of metastatic carcinoma comparing the status of the lymph node metastasis, comparison between the two groups was statistically significant(P < 0.05). Primary double mostly no lymph node metastasis carcinoma group, but most metastatic carcinoma group with lymph node metastasis. The pathological data show: Group of 24 cases of patients with primary double, 14 examples intrauterine membrane and ovarian sample at the same time for endometrial adenocarcinoma; 10 cases of endometrial and ovarian pathological types(including 2 example intrauterine membrane for endometrial adenocarcinoma, ovarian granulosa cell tumor; 4 example intrauterine membrane for endometrial adenocarcinoma, ovarian serous papillary cystadenocarcinoma; Example 2 intrauterine membrane for endometrial adenocarcinoma, ovarian mucous cystadenocarcinoma; 1 example intrauterine membrane for endometrial adenocarcinoma, ovarian of neuroendocrine carcinoma; 1 example intrauterine membrane for endometrial adenocarcinoma, ovarian clear cell carcinoma). Metastatic carcinoma in the group of 27 cases, endometrial and ovarian pathological types are the same, the two parts of the sample with endometrial adenocarcinoma. 11 cases of endometrial carcinoma bilateral ovarian metastasis, 16 cases of endometrial carcinoma unilateral transfers. Primary double carcinoma and metastatic carcinoma group in treatment, prognosis and survival was statistically significant(P < 0.05). Double through surgery and adjuvant chemotherapy and prognosis of cancer group was obviously better, than the metastatic carcinoma group has a good survival. Conclusions:1. Synchronous primary endometrial and ovarian carcinomas patients than in patients with primary endometrial cancer with ovarian metastasis age is small, most of the patients with menopause. Main symptom more, with abdominal pain and pelvic mass with ascites is less, mostly not seen vascular tumor emboli, and myometrium invasion depth is shallow, tumor differentiation degree, also have no lymph node metastasis. Synchronous primary endometrial and ovarian carcinomas the more early, should prevent the excessive treatment;2. Primary double cancer patients because of the endometrium and ovary respectively in the early stages of disease, patients with metastatic carcinoma group compared with good prognosis and survival.