Correlation Between Peripheral Neuropathy And Bone Mineral Density In Type 2 Diabetes

Objective:To investigate the relationship between peripheral neuropathy and bone mineral density in type 2 diabetes mellitus(T2DM)and its role in the occurrence and development of osteoporosis,so as to provide a theoretical basis for the early prevention and treatment of osteoporosis in T2DM patients with peripheral neuropathy.Methods:According to the diagnostic criteria of WH0 diabetes in 1999,300 T2DM patients(including 155 postmenopausal women and 145 males aged 50 or above)admitted to the endocrinology department of the First affiliated hospital of Soochow University from September 2017 to February 2018 were selected.According to the criteria for the diagnosis of osteoporosis(2011),these patients were divided into three groups,group 1(normal bone mass,113 cases),group 2(osteopenia,102 cases)and group 3(osteoporosis,85 cases),their basic information,biochemical indicators and vibration perception threshold of their feet are measured.SPSS20.0 software was used for statistical treatment.One-way ANOVA was used for the comparison of sample mean between multiple groups,Pearson was used for correlation analysis,and Logistic multiple stepwise regression was used to analyze the correlation between BMD and various factors.P<0.05 was considered statistically significant.Results:ANOVA showed that the vibration perception threshold in the osteoporosis group(left 19.11 ±8.29,right 17.99±7.24))was significantly higher than that in the normal bone mass group(left 9.24±3.53,right 9.04±2.95)and the osteopenia group(left 16.13±3.88,right 15.92±3.99)(P<0.05).Correlation analysis shows that VPT was positively correlated with age,ALP and arteriosclerosis,and negatively correlated with GFR.Logistic regression suggested that the influencing factors of BMD were:VPT(OR=3.281,P<0.001),ALP(OR=1.127,P=0.006)and gender(OR= 0.101,P=0.018)Conclusion:Bone mineral density is closely related to peripheral neuropathy in patients with T2DM.The development of peripheral neuropathy is often accompanied by decrease in bone mass,which is likely to lead to osteoporosis.