Study On Aminoarylation Of Alkenes By Copper Catalysis

Amino functionalization of alkenes is an effective means to prepare a series of bioactive amines which plays an important role in organic synthesis.In this thesis,we mainly studied the aminoarylation of alkenes by copper catalysis,which mainly includes the following three chapters:Chapter 1: Research progress of amino functionalization of alkenesIn this chapter,the strategies of transition metal catalysis,visible light catalysis and metal free catalysis were summarized in amino difunctionalization of alkenes field,such as hydroamination,aminocyanation,aminooxygenation,aminohalogenation,diamination and aminoarylation.Chapter 2: Study on copper-catalyzed aminoarylation of alkenesIn this chapter,we report a copper-catalyzed aminoarylation of alkenes involving the formation of dialkyl substituted amino radicals.In this reaction,Obenzoylhydroxylamine was used as amination reagent,and a series of α-aryl-β-amino substituted amides were successfully constructed.At the same time,it can be compatible with four membered rings,six membered rings,seven membered rings and ring opening substituted amines under mild conditions and simple operation,which greatly expands the universality of substrates.In addition,we also carried out control experiments to explore the reaction mechanism,and proved that the N-H bond finally formed in the reaction came from trace water in the reaction system.Chapter 3: ConclusionsIn this chapter,we describe the conclusions and prospects of this paper.