Study On The Reactions Of Alkenes For The Construction Of Carbon-Hetero Bonds

The bifunctional reaction of alkens can introduce two different functional groups at the same time,which has attracted the attention of synthetic chemists.In recent years,great progress has been made in the bifunctional reaction of alkenes catalyzed by transition metals.Researchers continue to develop new and effective synthetic methods to convert simple olefins into complex organic compounds.Among them,the participation of free radicals in alkene bifunctional groups is one of the most attractive methods and has been widely used in organic synthetic chemistry.Heteroatom compounds,especially nitrogen-containing compounds and phosphorus-containing compounds,have attracted people's attention because of their unique biological activities and their widespread existence in nature.As one kind of important organic compounds,it can not only be used as an important pharmaceutical intermediate,but also an important part of natural products and functional materials.Therefore,it is of great significance for the synthesis of some complex and valuable natural products and organic molecular frameworks to construct new carbon heterobonds through the transition metal catalyzed free radicals participating in the bifunctional reaction of olefins.This paper mainly focuses on the research of transition metal catalyzed free radicals participating in alkens bifunctional reaction and building new carbon heterobonds,the main contents include the following three parts:In the first chapter,the research progress of transition metal catalyzed alkylnitrile to produce alkylnitrile radicals and participate in the bifunctional reaction of alkenes and the research progress of transition metal catalyzed p-h-bonded compounds to produce phosphine radicals and participate in the bifunctional reaction of alkenes in recent years will be mainly introduced.In the second chapter,the nickel-catalyzed silver salt-mediated 1,2-alkylation esterification reaction between the three-component molecules of styrene and alkyl nitrile compounds and carboxylic acid derivatives was studied.In this method,Ag₂CO₃was used as a free radical initiator to construct C-C bond and C-O bond simultaneously through alkylation of alkyl nitrile radical and alkene.In this reaction,cheap nickel was used as Lewis acid to activate alkenes and stabilize free radical intermediates,so as to improve their reactivity.This method has the advantages of atom and step economy,and has a wide range of substrate adaptability.The reaction has been of great scientific application value in the medicine and natural product synthesis.In the third chapter,a nove-l series cyclization of N-methylacryloyl-2-phenylindole/benzimidazole with P-H bond was studied.In this reaction,Mn(III)compound was used as the free radical initiator,it shows good functional group tolerance,and can obtain various indole/benzimidazole Isoquinolinone compounds with high yield and wide substrate adaptability under relatively mild conditions.