Release Of Resveratrol And Electrocatalysis Study By Fe₂Ni MIL-88-derived Nanomaterials

The poor solubility is one of the main reasons for the low oral bioavailability of insoluble drugs.The successful loading of insoluble drugs with nanocarrier materials can construct the drug delivery systems to improve the solubility of insoluble drugs and increase the oral bioavailability.Therefore,it is highly vital to explore novel and efficient the drug delivery systems.Resveratrol is a kind of white powdery compound of polyphenols,which has outsdanding pharmacological effects such as anti-oxidation,anti-cancer,anti-inflammatory,cardiovascular protection and anti-aging.However,resveratrol has poor chemical stability,easy to be oxidized and low bioavailability.In order to increase the bioavailability of resveratrol,it is critical to select suitable nanocarriers.Metal-organic frameworks（MOFs）are a type of infinitely expanding one,two,and three-dimensional network structure formed by the connection of metal ions and organic ligands.MOFs and their derivatives have the characteristics of large specific surface area,adjustable pore size,and biodegradability,which can be used as drug carriers to improve the solubility of insoluble drugs and increase the bioavailability of drugs,so they are potential drug delivery materials.At the same time,MOFs are transformed into multifunctional composite materials with different structures by different transformation methods,which can be applied to catalysis,chemical separation and sensing.In this study,Fe₂Ni MIL-88 nanorods were synthesized by solvothermal reaction,and the Res-Fe₂Ni MIL-88 drug delivery system was successfully constructed.The p H responsiveness,stability,and material cytotoxicity of the drug delivery system were investigated.Secondly,through a simple annealing treatment,the magnetic Ni Fe₂O₄ nanomaterial derived from Fe₂Ni MIL-88 was prepared,and various indexes of the Res-Ni Fe₂O₄ drug delivery systems were evaluated.Finally,the Ni Fe₂O₄/Ni₃S₄ heterostructure catalyst was prepared,and the OER performance was tested and applied to the zinc-air battery.The main research contents are as follows:1.By adjusting the solvothermal reaction time,a series of Fe₂Ni MIL-88-x products were prepared.They exhibited nanorod morphologies,had different surface areas and pore sizes.The Res-Fe₂Ni MIL-88 drug delivery system was constructed by solvent volatilization method.The influence of carrier concentration and different carrier materials on the loading effect were investigated,and the appropriate Res-Fe₂Ni MIL-88 drug delivery system was selected.The successful loading of resveratrol was confirmed by XRD,DSC,UV-Vis and other characterization methods,and the drug loading capacity was 33.59%.The drug release curves in vitro showed that the carrier had good stability in neutral media,and the drug cumulative release was low;while in acidic media,the drug cumulative release was high due to the degradation of the carrier.Therefore,the drug release in the Res-Fe₂Ni MIL-88 drug delivery system had certain p H selectivity.The cytotoxicity of the carrier was detected by MTT method.The survival rate of LO2 cells was over 87%in the range of 10-100μg/m L carrier concentra-tion,indicating that the carrier had good biocompatibility.2.By controlling the annealing time,the magnetic Ni Fe₂O₄ material derived from Fe₂Ni MIL-88 was prepared.Characterization methods such as BET,XRD and SEM showed that the crystallinity and specific surface area of the carrier gradually increase as the calcination time was extended.The Res-Ni Fe₂O₄ drug carrier system was constructed by solvent volatilization to investigate the influence of different carriers on the loading effect,and the optimal drug-carrier system was established.The XRD and DSC characterization methods proved that Res was successfully loaded with a drug load of 41.35%.The drug release curves in vitro showed that Ni Fe₂O₄could improve the solubility of Res,and the drug release had certain p H responsiveness.The cytotoxicity of the carrier was investigated by the MTT method,and studies had shown that the carrier had good biocompatibility.3.Through solvothermal reaction and annealing treatment,the Ni Fe₂O₄/Ni₃S₄ heterostructure derived from Fe₂Ni MIL-88 was prepared.An obvious heterogeneous interface was formed between the two species,and the existence of charge transfer,abundant oxygen vacancies and cationic effects at the interface,so Ni Fe₂O₄/Ni₃S₄ had excellent electrocatalytic activity.The catalyst was used as a cathode in zinc-air batteries and had excellent stability and zinc-air batteries performance.In this study,a simple and feasible method was used to synthesize the heterostructure Ni Fe₂O₄/Ni₃S₄,which laid the foundation for the synthesis of metal-air battery cathode materials.