Release Of Insoluble Ibuprofen And Electrocatalysis Study By MIL-88A-derived Nanomaterials

Insoluble drugs significantly limit the oral utilization of drugs,which is a major obstacle to clinical application.With the rapid development of nanomaterials,it is found that the solubility of insoluble drugs can be effectively improved once they are confined in nanochannel structures.Novel nanostructured mesoporous materials with this type of structure have been gaining increasing wide-spread attentions.Thanks to its abundant pore channels,high specific surface,and the confinement effect can effectively reduce the drug crystallinity,nanostructured mesoporous materials have been continuously playing an important role in the fields such as drug delivery,luminescence probe and magnetic resonance imaging and so on.As a gradually developing new discipline,nanomaterials have an important influence in the field of medicine.In addition to many typical nanoparticles as medical materials,there are even popular single atom catalyst and heterojunction catalysts in clinical medicine.Single atomic Fe catalyst can effectively induce tumor-specific in situ Fenton reaction and lead to malignant tumor cell apoptosis in acidic TME medium.Oxygen evolution reaction（OER）can catalyze a series of intracellular biochemical reactions,so that the production of ROS,in the absence of external stimulation and under hypoxia conditions has a significant specific inhibitory effect on tumor growth.As a result,the relationship between catalysis and pharmaceutical nanomaterials has been slowly established.In recent years,transition metal compounds not only show good catalytic performance,but also can be employed as efficacious drug carriers.In this study,firstly,metal organic framework MIL-88A was used as the precursor,whose mesoporous structure was further optimized by adjusting the hydrothermal time,and MIL-88A was evaluated as drug loading material.Secondly,the magnetic material Fe₃O₄,with rich pores and high specific surface area was prepared by optimizing the calcination time of MIL-88A,and the insoluble drug ibuprofen was loaded on Fe₃O₄ to form a composite,and the adsorption and release,loading and cytotoxicity of the composite were evaluated.Finally,the heterostructure catalysts of MIL-88A and Ni（OH）₂were prepared and applied to OER.Such heterostructure catalyst exhibited excellent OER performance and can be used as an ideal anodic catalyst for water splitting.The main research contents are listed as follows:1.Using metal organic framework（MIL-88A）as drug loading substrate,MIL-88A-x with different specific surface areas and pore sizes were prepared by adjusting the hydrothermal time,and the MIL-88A with optimal pore structure was obtained.In addition,the drug loading amount of MIL-88A,the drug dissolution in different solution media,the stability of drug composites and the cell survival rate were also examined.Finally,combined with the density functional theory calculations,the adsorption energies and adsorption sites of ibuprofen adsorbed on different crystal surfaces of MIL-88A were simulated,and the property parameters of MIL-88A as a drug carrier were systematically investigated.2.The magnetic Fe₃O₄ nanomaterials derived from MIL-88A was prepared by controlling the calcination time.The specific surface area and mesoporous structure of Fe₃O₄ were apparently superior to MIL-88A,then we employed multiple characterization methods,including XRD,TEM and SEM,to select the optimal drug loading materials,plus the corresponding characterization,it is confirmed that ibuprofen was successfully loaded into the carrier materials.Subsequently,we evaluated the drug dissolution,drug loading and magnetic adsorption properties,and the most representative 311crystal plane was chosen to explore the Fe₃O₄ adsorption kinetics for ibuprofen in conjunction with density functional theory.Finally,we evaluated the cytotoxicity of the carrier material and the optimal cell concentration of Fe₃O₄ as the drug carrier material was obtained.3.Through rational design,we successfully prepared the heterostructure self-supporting electrode material of MIL-88A/Ni（OH）₂-CC derived from MIL-88A.Due to the charge transfer at the heterostructure interface,MIL-88A become more positively charged,so it is easier to adsorb OH^-in electrolyte solution.Secondly,some high valent Fe species are induced due to the effect of applied voltage and charge compensation,where high-valent Fe species has been confirmed as the active center for OER,hence active sites for OER can be continuously generated.The heterostructure self-supporting electrode material of MIL-88A/Ni（OH）₂-CC has excellent OER performance and can be empolyed as a cathode material for full water splitting device and metal-air batteries,and hold the potential for industrial production as well.