Preparation And Electrochemical Properties Of New Structure ZIF-67 Derivative And Application As Drug Carrier

With the continuous advancement of science and technology,the continuous development of human civilization,the increasing population base,and the demand for drugs have also increased significantly.Oral drugs have become the main way to absorb human drugs because of their convenience and speed.However,some difficulties are difficult.The oral availability of soluble drugs is very low,due to their low solubility in water,which leads to great limitations in the clinical application of these drugs,and mesoporous carbon nanomaterials can improve this problem.Because of its high specific surface area,rich and adjustable pore size and pore structure,relatively large pore volume,and good stability,these materials have high potential in the transportation and delivery of drugs.At present,the research on mesoporous carbon is mostly spherical mesoporous carbon.The traditional synthetic methods include hydrothermal method,stencil method and aqueous solution method.However,these synthetic methods and spherical structures have some disadvantages,such as high synthesis cost,the yield is low,the synthesis steps are complicated,the dispersibility is poor,and the pore structure is poor.This greatly limits the practical application and promotion of mesoporous carbon materials in drug loading.Therefore,the study of non-spherical new structure mesoporous carbon materials has attracted much attention.Mesoporous carbon materials are not only widely used in the pharmacy,but also play an important role in the electrocatalysis.Rechargeable Zn-air batteries have attracted considerable attentions due to various advantages,such as the abundant Zn element in earth crust,low production cost,high theoretical energy density,low environment impacts and so on.Moreover,because Zn-air batteries normally employ aqueous electrolytes which have a relatively high boiling point,the potential safety risks encountered in the mainstream lithium-ion batteries that usually utilize volatile and flammable organic liquid electrolytes can be significantly reduced.Currently,rechargeable Zn-air batteries represent one of the viable and promising electrochemical energy storage and conversion technologies and hence are growing in popularity for portable electronics,electric vehicles,aerospace applications,storage of intermittent green energy from sunlight and wind etc.In this article,through the development of a more green and simple method,the metal organic framework ZIF-67 and ZIF-8 are used as precursor materials to design and synthesize metal-nitrogen-doped mesoporous carbon nanomaterials by scanning electron microscopy?SEM?and transmission electron microscopy?TEM?,X-ray photoelectron spectroscopy?XPS?and other characterization methods to analyze the morphology,structure,elemental composition and electro-catalytic activity of materials to analyze the composition,structure and electrochemical activity of materials.In the relationship,the synthesized mesoporous carbon material was used for the adsorption of the poorly soluble drug ibuprofen,and the drug dissolution release rate,material loading amount and cytotoxicity of the material were investigated,and it was loaded on the cathode of the zinc-air battery to explore its relationship.Catalytic performance.The main research contents are as follows:?1?The experiment use Co?NO₃?_2,graphite-type carbon nitride?g-C₃N₄?as raw material,ZIF-8 as precursor,and synthesize ZIF-8derivative at room temperature,and prepare cobalt by calcination under argon?Ar?atmosphere.Zinc?Zn?metal co-doped mesoporous carbon nanomaterial Co,Zn@NC-T?T is the calcination temperature?.The morphological characteristics,pore volume and structural elements of nanomaterials Co,Zn@NC-T synthesized at different calcination temperatures?700?,800?,900??were further analyzed to compare nanomaterials synthesized at different calcination temperatures.Oxygen reduction?ORR?electrocatalytic performance.This experiment provides experimental ideas and foundations for the synthesis of ZIF-67-derived materials Co@NHCC.It is a pre-experiment of ZIF-67-derived materials.Therefore,this article does not describe the characterization and properties of Co,Zn@NC.?2?Using graphite-type carbon nitride?g-C₃N₄?as raw material,ZIF-67 as precursor,using silica?SiO₂?nanosphere as template,synthesizing ZIF-67 derivative in methanol reaction system under argon conditions Mesoporous carbon nanomaterials containing cobalt?Co?metal nitrogen doping were prepared by high temperature carbonization.The material was a highly graphitized polyhedral hollow carbon nanocage Co@NHCC-T with porous thin carbon walls,and different calcination temperatures were observed.The morphology of the material at 700?,800?,and 900? was analyzed by elemental analysis.The electrocatalytic properties of the materials at different calcination temperatures were also compared.It was found that Co@NHCC-800 is the highest with the highest ORR and OER properties.Functional electrocatalyst.In the application of a rechargeable zinc-air battery,when used as a gas permeable electrode in a rechargeable zinc air battery,it exhibits an open circuit voltage of 1.49 V higher than that of a commercial Pt/C catalyst,and a maximum discharge of 248 mW cm^-2.Power density.After 12 hours of continuous cycle of charge-discharge measurement,the charge-discharge voltage gap increased only slightly by 10 mA cm^-2.?3?The experiment further explored a series of topographical structures and pore size distributions of materials Co@NHCC-700,Co@NHCC-800,Co@NHCC-900 and Co@NCPT-800.By observation and comparison,Co@NHCC-800 exhibited a large specific surface area of about 910.71 m²·g^-1.The adsorption performance of the material as a drug carrier on the poorly soluble drug ibuprofen was compared.By observation and comparison,the adsorption,release characteristics and cytotoxicity of mesoporous carbon materials on model drugs were investigated by UV spectrophotometry and CCK-8 method.Co@NHCC-800 with larger specific surface area and more pores was found.The model drug carrier can significantly improve its adsorption performance and cumulative dissolution release to poorly soluble drugs,and exhibits good biocompatibility.