Research On The Construction And Application Of Danshensu Electrochemical Sensors

Danshensu is a biologically active compound isolated from the traditional Chinese medicine salvia miltiorrhiza.It has an assortment of valuable pharmacological effects including expansion of coronary arteries,anti-tumor,anti-inflammatory,anti-oxidation,protection of organ damage and enhancement of human immunity,and has been clinically applied.It is of great value for the development of high-efficiency,low-cost,highsensitivity Danshensu detection platform and the study of the functional mechanism of Danshensu.The electrochemical method can accurately determine the content of Danshensu,and can be made into a miniaturized and portable device in practical applications.It is efficient and convenient.It is an advanced quantitative detection method for Danshensu.In addition,electrochemical methods also help to study the redox of Danshensu and provide important information about pharmacological effects.In this study,an electrochemical sensor was constructed with the help of two composite materials of covalent organic frameworks(COFs)and single-atom catalysts to achieve the high sensitivity,wide range and high selectivity of the quantitative detection of Danshensu.1)The crystalline porous polymer COF-V is prepared by solvothermal method,which has a large surface area and easy-to-customize functionality.The Au nanoparticles(Au NPs)are combined with Au-S bonds and them combined with the high-conductivity material3 D r GO to realize the construction of the Danshensu electrochemical sensor.The electrochemical sensor makes full use of the adsorption capacity of COFs on Danshensu,with the help of Au NPs to catalyze Danshensu and 3D r GO to improve the conductivity of the composite material,realizing efficient and sensitive quantitative detection of Danshensu.2)The single-atom synthesis coordination-calcining technique fixes tin atoms on Ndoped multi-walled carbon nanotubes to form a stable Sn-N-C structure.This material has the advantages of high active site density,large specific surface area and good electrical conductivity.It is used as a modified material to be dripped on the surface of glassy carbon electrode to construct an electrochemical sensor to quantitatively detect Danshensu,showing high sensitivity and high selection.And has a wide detection range.This is the first time that a single-atom catalyst has been used in electrochemical sensors to detect Danshensu and has certain application value.In summary,the two Danshensu electrochemical sensors exhibit high sensitivity,wide detection range,high repeatability and excellent selectivity.They enrich the electrochemical analysis content of Danshensu.It also speeds up the application of COFs and single-atom catalysts in the electrochemical field,and also provides ideas for electrochemical sensors for drug analysis.