| Amido is one of the most common functional groups in organic chemical systems,and constitutes the basic component of various biologically meaningful natural products,drugs and pesticides.In recent decades,researchers have conducted a lot of research on the synthetic methods of amides,so the synthetic methods of amide compounds have been perfected by previous researchers.Due to its low toxicity,good stability and easy availability,iodine reagents play a vital role in the catalytic synthesis of amide derivatives.This article reviews the common methods for synthesizing amide compounds and the methods catalyzed by iodine reagents.The second chapter of this thesis discusses the method of breaking the C-N bond to form a primary amide compound under the catalysis of a high iodine reagent.N-quinolinecarboxamide is an important class of compounds in metal-catalyzed directional C-H functionalization reactions,and the quinoline group in the molecule is a widely used protecting group and guiding group.However,the development of a simple method capable of removing quinoline protecting groups has important academic significance and application prospects.In this paper,we describe a method in which a high iodine reagent participates:by using a mixed solvent of H2O and HFIP,2-iodoacrylic acid oxidizer or a catalytic amount of 2-iodobenzoic acid and Oxone oxidant,Various N-quinolinecarboxamides are converted to primary amides.This method has specific selectivity and can achieve high yields,and has achieved significant results in the application of removing quinoline protecting groups.The third chapter discusses the promotion of iodine element,through the direct addition of aryl and cyano N atom to obtain a variety of useful secondary amide compounds,this method is a metal-free,alkali-free and solvent-free cross-coupling reaction.Experiments show that the aryl transfer reaction is carried out by using the hydrochloride salt of arylhydrazine as the aryl donor,and an N-labeling experiment has been tried,which proves that the N atom in the product comes from the lower cost nitrile cyano group.The method has mild conditions and a wide range of substrates,which lays the foundation for further expansion of iodine-catalyzed synthesis of amide compounds. |
