Study On Aryl Transfer Reaction Promoted By Iodinereagent

This dissertation mainly deals with the following two aspects: 1.Hypervalent iodinereagents-promotedthe synthesis of amides;2.Iodine-promotedthe synthesis of amides.1.Hypervalent iodinereagents-promotedthe synthesis of amides.Amide moiety is widely found in natural products,many alkaloids(such as colchicine,mountain base and ergot base),and drugs(atorvastatin,lisinopril and diltiazem,etc.).In addition,amides are also important intermediates in the synthesis of pharmaceuticals,pesticides,fuels,and pigments.Therefore,the synthesis of amides is also one of the hotspots in organic synthesis chemistry.In this work,we developed a method of hypervalent iodine reagents-promoted the synthesis of amides starting from acetohydrazides and nitrilesvia an aryl transfer reaction.The adventages of thenewmethod are involved of readily avilable substrates,metal-free conditions,simple operation,and moderate to good yieslds.2.Iodine-promoted synthesis of amide.A further investigation on the study disclosed that aromatic hydrazine hydrochlorides can also afford the same amides via similar aryl transfer reactions with nitrile compoundsin the presence of I2-t BuONO system at room temperature under solvent-free conditions.