Design,Synthesis And Properties Of Ionic Liquid-Based Antibacterial Coatings

Bacterial colonization on the surface of medical implants not only seriously damages the function of implants and exposes patients to the risk of systemic infection,but also makes conventional systemic antibiotic therapy basically futile once mature biofilms formed,resulting in significant increases in medical costs,morbidity and mortality.Therefore,how to prevent bacteria from sticking and colonizing on the surface of implants and killing bacteria on the surface and surrounding areas is one of the important challenges facing medical implants at present.Chronic infection caused by bacteria and fungi is one of the most common infections.At present,chronic infections are mainly treated by systemic antibiotic treatment or applying topical ointment on chronic wounds Systemic antibiotic treatment is not targeted and high-dose antibiotic treatment is easy to lead to the problem of bacterial resistance,while local drug application cannot play an effective therapeutic role due to poor drug permeability.Therefore,it is extremely urgent to develop targeted local treatment strategies.The microneedle patch composed of microneedle tips can puncture skin barriers,enhance drug permeability,successfully deliver antibacterial agents to wound infection sites in a minimally invasive way,and has unique advantages for inhibiting and treating chronic wound infection.This paper focuses on the molecular design of antibacterial materials,designs and prepares antibacterial materials applied in different scenarios in different forms.The specific research contents are as follows:1)To solve the problem of infection related to medical devices,a new antibacterial antifouling coating was constructed.Construction and properties of NO-releasing ionic liquid based anti-fouling coatings.The quaternary ammonium ionic liquid(IL8)and 2-methyl-2-acrylate-2-(2-methoxyethoxy)ethyl ester(DEGMA)were covalently grafted to the surface of medical grade PDMS by chemical grafting method.Further,the ionic liquid-based antifouling coating(PDIL-Pro-NO)was constructed by converting Br^-into proline anion(Pro^-)to adsorb NO gas.The results of antibacterial and antifouling properties of PDIL-Pro-NO showed that PDIL-Pro-NO had a stable long-term(>7days)antibacterial activity(>98%)against E.coli and S.aureus.At the same time,PDIL-Pro-NO had good anti-protein adhesion,anti-bacterial adhesion and biocompatibility.Animal subcutaneous implantation experiments showed that PDIL-Pro-NO exhibited good antibacterial and anti-inflammatory properties in vivo.2)In order to solve the problem of skin wound infection,a novel antibacterial microneedle with photothermal properties(Zr-Fc MOF@MN)was prepared by using polyvinyl alcohol(PVA)and polyvinylpyrrolidone(PVP)as microneedle carriers and supported by a metal organic framework with photothermal effect(Zr-Fc MOF).The synthesized Zr-Fc MOF and Zr-Fc MOF@MN were characterized by photothermal and antibacterial properties.The temperature changes with time under different concentrations of MOF materials and different laser densities were studied.The experimental results show that Zr-Fc MOF has good photothermal properties.The temperature of Zr-Fc MOF(0.4 mg/m L)can rise to 57.4°C after 10 min of 2.6 W/cm~2 laser irradiation.The prepared Zr-Fc MOF@MN has a good antibacterial effect under near-infrared light for 10 min.