Study On The Structure-antibacterial Properties Of Antibacterial Materials Based On Imidazolium-type(Poly)ionic Liquids

Bacterial infection is a serious threat to human health,with the widespread use of antibiotics,drug resistant bacteria are rapidly emerging.Traditional antibiotics are very difficult to cure the infections caused by antibiotic resistant bacteria,so it is necessary to develop the new antimicrobial drug or materials.Antibacterial materials are a kind of new functional materials that inhibiting or killing microbe.At present,the study of organic antibacterial materials is mainly concentrated on cationic compounds or polymers.Due to its unique structure ionic liquid is selected as antibiotics or the main component of antibacterial materials.Both antibiotics and antibacterial materials,the basic structure of the compound is the key point for the performance of antibacterial property.At present,the structure research of most antibiotics or antibacterial material is limited to one of the areas of small molecular or polymers,for the research in monomer-polymer-materials system,the performance affected by the whole system is nearly be reported.How to predict the antibacterial properties of polymer materials by structural design of small molecules is still a challenge in the design process of antibacterial materials.In view of the above research status,we used ionic liquid as monomer,a series of homopolymers and membrane materials were synthesized by changing the structure of anion and cation.A comprehensive discussion was carried on structure-antibacterial properties.The research contents and main conclusions are as follows:（1）The number of N-3 replaced alkyl chain length and imidazole ring（positive charge density）were chosen as the main structural factors,a series of imidazolium ionic liquid monomers,homopolymers and membrane materials were synthesized.The antibacterial properties amount ionic liquids,homopolymers and membrane materials were discussed based on the alkyl chain length and positive charge density.The relationship amongst the antibacterial properties of imidazolium ionic liquid monomer and its corresponding homopolymer and copolymer membrane was analyzed.The results show that the antibacterial activities of both ionic liquid monomers and homopolymers were improved with the increase of the alkyl chain length and higher charge density（bis-cations）of imidazolium cations.However,the antibacterial activities of membranes increased with the charge density（bis-cations）while decreasing with the increase of alkyl chain length.At the same time,we obtained membrane material with good antibacterial effect and excellent biocompatibility.（2）Study on the structure and properties of antibacterial materials based on metal coordinated（poly）ionic liquids.Herein,imidazolium-type ionic liquid monomers and their corresponding poly（ionic liquid）membranes were synthesized based on the coordination between Br^-and CuCl₂,FeCl₃ and ZnCl₂.The antibacterial property of these substances was studied.The synthesized IL monomer coordinated with CuCl₂exhibits the highest antibacterial efficiency.Similarly,the PIL membranes based on the coordination of CuCl_2,also showed better antibacterial activity than the others.Furthermore,all the PIL membranes presented good biocompatibility.