Study On Organic/Inorganic Composite Nanoparticles In Synergistic Therapy Of Tumor

In recent years,significant progress has been made in the treatment and research of cancer,but it is still one of the leading diseases affecting human health in the world today.The proportion of survival has only increased slightly in recent years.Traditional treatments include chemotherapy(CT),radiation therapy(RT),photothermal therapy(PTT),and photodynamic therapy(PDT);in addition,new emerging immunotherapy,gene therapy,and hunger therapy are all glorious in the field.But it is difficult to achieve the desired effect with a single treatment.If a composite nanomaterial is designed,combining two or more treatments to overcome the deficiencies of a single treatment can minimize the hazard.Achieve "1+1>2"effect to optimize treatment.Gold-based nanomaterials(golden balls,gold bars,gold stars,gold nanocage,etc.)are particularly prominent in the treatment of tumors.Among them,the photodynamic therapy of gold rod has been applied to the clinic;in addition,gold as a material with high atomic number has the natural advantage of radiotherapy.When radiotherapy is introduced,the produced reactive oxygen species(ROS)can act on the plasmid DNA of the cancer cells,causing the double-stranded DNA to be broken and irreparable.In the second chapter,the golden ball is first synthesized and coated with bovine serum albumin(BSA).BSA as a natural protein has a good modification effect,which can increase the biocompatibility of the nanoparticles while the surface amino group and carboxyl group can be further modified.Doxorubicin hydrochloride(DOX),as a chemotherapy drug that has been put into clinical use,can achieve the organic combination of radiotherapy and chemotherapy by electrostatic adsorption on BSA.In addition,the group on the BSA can be coordinated with Gd3+ ions to achieve nuclear magnetic resonance(MRI)imaging.Experimental data indicates that synergistic therapy is more effective than monotherapy,and tumor recurrence is almost zeroTumor multidrug resistance(MDR),hypoxemia oxygen,etc.make the effect of chemotherapy is not ideal.If we can improve the hypoxic microenvironment first,then apply chemotherapy drugs,which can greatly enhance the cytotoxicity of DOX With the rapid development of energy materials,in Chapter 3,we envisage the use of energy materials for the treatment of tumors.The rutile titanium dioxide(TiO2)supported cobalt oxyhydroxide(Co(OH)2)was selected as the main component(NCs)We know that the mechanism of photodynamic therapy is that the photosensitizer stimulates the triplet oxygen molecule O2 to produce ROS.This treatment will make the hypoxic tumor microenvironment(TME)more hypoxemia after O2 consumption The effect will only be significantly weakened.NCs can photolyze endogenous water molecules to produce oxygen under 660nm illumination,which can alleviate the hypoxia of TME.The polydopamine(PDA)shell was coated on the CT to increase the biocompatibility of the inorganic nanocarriers,and DOX was stacked by π-π.The experimental results show that a small amount of DOX can kill a large number of cancer cells after oxygen production;compared with a single DOX treatment,the MDR is greatly alleviated by hypoxia.