| Equine neuroaxonal dystrophy (eNAD) is an inherited neurodegenerative disorder in horses. Previous clinical studies show evidence that vitamin E deficiency may be involved in the development of eNAD. In this study, we investigated genetic variations in several candidate genes responsible for vitamin E metabolism. One variant at chr17:71585141 was identified to be significantly associated with the eNAD phenotype (PBonferroni= P=0.002). However, a review of the Sequence Read Archive (SRA) database indicated that the allele frequency of this variant in the eNAD affected population is similar to that of the general population. |
