Dynamics of DNA Looping in Nanochannels

This thesis is devoted to the study of protein-DNA interactions and especially how proteins can mediate DNA loop formation in nanochannels. In the last decade, a large number of studies have been performed, wherein DNA molecules were confined to the channels with cross-section around the persistence length of DNA molecule. Such nanochannels provide a good model system for studying of the physics of confined DNA. The results of this thesis increase our understanding of how different DNA-binding proteins can change the DNA configuration. (Abstract shortened by ProQuest.).