| This thesis addresses methodological issues of the glycemic index (GI) concerning within and between subject variation. The objective of study #1 was to determine whether controlling the subjects' prior activities reduces the within-subject variability of glycemic responses. The CV (%) of controlled trials was not significantly different from that of the uncontrolled trials, and tended to increase the variation. The objective of study #2 was to determine if relative blood glucose and insulin responses were the same in men with varying insulin sensitivity. Relative blood glucose responses were similar between insulin sensitive and insulin resistant men, although relative blood insulin responses significantly negatively correlated with fasting insulin concentrations. It is concluded that within-subject variation is not reduced by controlling prior activities, and the GI is a valid tool in people with varying insulin sensitivities, however the insulineamic index (II) may not be as useful due to the variation between people. |
