| Jun/Fos and Jun/BATF heterodimers are capable of binding the TRE site to regulate gene transcription, which in turn amongst other functions, could be involved in the regulation of inflammation. Studies have shown that in contrast to Jun/Fos, the Jun/BATF heterodimers result in a reduced transcriptional activity and thus inhibit the expression of AP-1 target genes. The inflammatory response is composed of a vast array of mediators, including cytokines such as IL6 and IL10. The balance between pro-inflammatory and anti-inflammatory mediators, in part, determines whether the inflammatory response persists or is resolved. Macrophages are a key cell type involved in the inflammatory response.;The goal of this research was to determine the expression of BATF in comparison to Fos expression when M1 cells were stimulated with the known inflammatory triggers, IL6, IL10 and LPS. Although M1 cells do not express c-Fos, they do express Fra-1, which is also a member of the Fos family. |
