| The objective of this thesis was to determine the effect of composition of fats and carbohydrates on food intake suppression by cholecystokinin. Fat (coconut oil, beef tallow, olive and safflower oil) and carbohydrate (cornstarch, sucrose, glucose, fructose) preloads were given intragastrically (1g/4ml) 30 min before feeding. Devazepide (0.25 mg/kg), was given intraperitoneally at 60 or 30 minutes before or with each of the macronutrient preloads. Devazepide reversed food intake suppression caused by all fat and carbohydrate sources but the effect was not consistently related to the time of devazepide administration or to any specific feeding interval. Among the macronutrients, the effect of coconut oil and glucose on food intake was reversed most by devazepide. It is concluded that fat and carbohydrate induced suppression of food intake occurs, at least in part, by a mechanism involving CCKA receptors but the composition of fat or carbohydrate is a determinant of the response. |
