| Molecular recognition has been applied to a variety of scientific areas. Considering the double complementary principle, numerous small molecules have been designed and showed potential practical use.; We have made efforts to utilize intermolecular interactions to realize a self-assembly system, molecular recognition of a protein surface and inhibitor design. (6-Decanoylamino-pyridin-2-yl)-propynoic acid and other derivatives containing complementary hydrogen bonding groups were designed, synthesized and studied as self-assembling systems by 1H NMR spectroscopy. As an extended design of calix[4]arene-based receptors for protein surface recognition, we have synthesized calix[4]arene scaffolds containing various groups in the lower rim. Compared to the aliphatic chains, other functional groups in the lower rim have been revealed as poor receptors for the surface recognition of cytochrome C. Proteasome inhibitors have been investigated as novel antitumor targets. CEP1612 prevented the increase of tumor volumes. We have evaluated the vicinal tricarbonyl group as a proteasome inhibitor as potential advantage of additional P′ sites. Peptidomimetic inhibitors containing biaryl scaffolds have been devised as mimics of extended conformation. Other efforts have been made to synthesize Echinoclathrin A as a potential proteasome inhibitor and methionine derivatives via regiospecific ring opening of the [3.1.0]-γ-lactone system, which can be applied to the synthesis of lignans containing a γ-lactone. |
