The Research On Synthesis And Properties Of Ions Recognition Receptor

In recent years, it is very important that the quantitative detection of heavy metals inpharmaceutical, food, clinical and environmental detection; Also, anion detection plays anextremely important role in chemical, life sciences and environmental science. So it has avery important research value to design the simple structure, ease-to-synthesis of colorimetric/fluorescent probe, which could sense heavy metal ions and anions with high selectivity. Inview of this, the paper designed and synthesized several probe molecules, which could detectspecific anion and cation. In addition, we studied its ion recognition performance. The thesisincluding the following four parts:Chapter One: Summary of LiteratureThis one elaborated the concept of molecular recognition, the mechanism and currentsituation of ion recognition. It mainly introduced the research progress of cyanide anion andcation recognition.Chapter Two: Synthesis of Cyanide anion probe based on Azosalicylic Aldehyde ofBenzoyl Hydrazone and its colorimetric sensing PropertiesA colorimetric sensor L1bearing Azosalicylic Aldehyde of Benzoyl Hydrazone wassynthesized. The binding properties of the sensor L1with anions such as F, Cl, Br, I,AcO, H2PO4, HSO4, ClO4, CN and SCN, were examined by UV-Vis spectra. The resultshowed that sensor L1has behaved good selectivity and high sensitivity for CN inDMSO/H2O (v/v,5:5) binary solutions. When CN was added to the solution containing L1,a dramatic color change from colorless to red was observed, while the other anions did notcause noticeable changes. And the detection limits were5.0×10-5M and3.7×10-8M of CN from visual color changes and UV-Vis spectrum changes respectively. Furthermore, test stripsbased on sensor L1were fabricated, and sensor L1could be served as practical colorimetricsensor to detect CN for―in-the-field‖measurement.Chapter Three: Synthesis of a new dual-function probe and its propertiesDesigned and synthesized a colorimetric sensor L2based on azobenzene and hydrazidegroups as signal report and potential anion recognition group, respectively. The bindingproperties of the sensor L2with anions and cations were examined by UV-Vis absorptionspectra. The result showed that it has behaved a good selectivity and high sensitivity for CN in DMSO/H2O (v/v,5:5) binary solutions and it can recognize Cu2+with high selectively in DMSO/H2O (v/v,8:2) binary system, which could be observed by naked eyes. The sensorachieved the dual response of Cu2+and CN. It would have a good application in the future.Chapter Four: Synthesis of a Hg2+fluorescent probe with high selectivity and itspropertiesA simple fluorescent sensor molecule L3was design and synthesis. The sensingproperties of the sensor with cations were examined by Fluorescence spectroscopy. InDMSO/H2O (v/v,9:1) binary solution of the sensor L3, with the adding of Hg2+, the sensordisplayed an obvious significant fluorescence quenching phenomenon, and the adding ofother cations such as Fe3+, Ag2+, Ca2+, Cu2+,Co2+, Ni2+, Cd2+, Pb2+, Zn2+, Cr3+and Mg2+didn‘tcause apparent interference for the recognition of Hg2+. In addition, we also studied itsrecognition mechanism by NMR and mass spectrometry.