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Finite element modeling of transcranial electrical stimulation in human brain

Posted on:2013-06-05Degree:M.SType:Thesis
University:Saint Louis UniversityCandidate:Jiang, PengjieFull Text:PDF
GTID:2454390008976675Subject:Engineering
Abstract/Summary:
Since it was proved that extracellular stimulation could evoke the neuron action potential in the brain, Transcranial Electrical Stimulation (TES) has become one of the most efficient methods to treat patients with diseases that decrease or completely deactivate neurons. This study seeks to determine the relationship between current density and electrode parameters during TES by using the finite element modeling method. The model was constructed from real Magnetic Resonance Images in Mimics. By using a high-speed computer, the model was meshed into a finite element model. After applying constant voltage electrodes as the boundary condition, the FEM was analyzed using existing software tools. Two types of electrodes were investigated, point-like electrodes and 2×2cm 2 pad electrodes. Comparing the results of two types electrodes and results of other studies, this study provides reliable evidence that manipulation of electrode size and placement in TES can be used to selectively stimulate action potentials in the cerebral cortex.
Keywords/Search Tags:TES, Finite element, Stimulation, Model
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