| Rationale: Sleep disruption is a widely known problem among chronic rhinosinusitis (CRS) patients. Previous studies have shown an increased rate of obstructive sleep apnea (OSA) in CRS patients. However, there is very little known about the risk factors of developing OSA in CRS patients and how CRS can impact sleep architecture in OSA.;Methods: In this study we have for the first time investigated the effect of CRS on OSA. This is a case-controls study using data from Rush University Medical Center electronic medical records.;Results: Two hundred-forty-six subjects were included, 109 are diagnosed with CRS and OSA and 137 are the control subjects with only OSA without CRS. Our results show that CRS + OSA subjects have lower body mass index (BMI) compared with OSA Only subjects (P-value <0.05). The mean age of CRS + OSA was significantly higher than the OSA only group. The sleep architecture was similar between the two groups, except higher PML index in CRS group.;Conclusion: The Lower BMI in the CRS + OSA group indicates a possible contribution of CRS in the development of OSA in individuals who are at lower risk based on their body habitus. The higher age of CRS + OSA subjects could be because these cases are developing OSA in the context of long-standing CRS. The increased periodic limb movement (PLM) during sleep in CRS patient with OSA compared with only OSA group needs further investigation and might indicate a possible association between CRS and restless leg syndrome. |
