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Clinical outcomes following pre- and post-operative Vitamin D supplementation in Roux-en-Y Gastric Bypass patients

Posted on:2013-08-30Degree:M.SType:Thesis
University:University of WashingtonCandidate:Neilson, CharlotteFull Text:PDF
GTID:2454390008466596Subject:Health Sciences
Abstract/Summary:
Background: Bariatric surgery is associated with risks for micronutrient deficiencies. For example, hypovitaminosis D (25(OH)D ≤30ng/mL) has been reported in obese individuals and patients who received Roux-en-Y gastric bypass (RYGB). Investigations on incidence of hypovitaminosis D in patients undergoing bariatric surgery in the Pacific Northwest are limited. The primary aim of this study was to identify the incidence of hypovitaminosis D in patients prior to RYGB. The relationship between 25(OH)D status and patient characteristics (age, gender, ethnicity, BMI, comorbidities) was analyzed. The secondary aim was to analyze longitudinal change in 25(OH)D concentration 1 year post-operatively.;Methods: A cohort study involving adult patients undergoing RYGB was conducted. Longitudinal change in serum vitamin D concentrations and clinical parameters were collected.;Results: Baseline data were analyzed in 134 patients. Hypovitaminosis D was identified in 90 patients (incidence of 67%), and was significantly affected by seasonal change and the number of comorbidities. Longitudinal data were available in 60 patients. Vitamin D sufficiency was achieved in 62.5% of those patients with baseline vitamin D insufficiency. A dose-response relationship of vitamin D intake was observed, with the most significant increase in 25(OH)D associated with daily vitamin D intakes ≥2000IU.;Conclusions: A significant number of patients have hypovitaminosis D at baseline. Daily vitamin D intake meeting at least 2000IU is associated with greater improvement in serum vitamin D concentration.
Keywords/Search Tags:Vitamin, Associated
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