| The first study compared tissue distribution of selenium, administered orally, at different doses of sodium selenite and selenomethionine. The bioavailability of selenium given as selenomethionine was significantly higher than selenium given as sodium selenite. Acute toxic effects in terms of clinical, clinicopathologic, and histopathologic evaluations were also described. Sodium selenite significantly lowered the liver vitamin E concentrations but no such depletion was seen with selenomethionine.;The second study compared the acute, oral dose kinetics of sodium selenite and selenomethionine, in serum and blood. Differences between these administered forms of selenium were reflected in the rate constants and intercepts. Selenium as selenite was not accumulated in erythrocytes, but selenium as selenomethionine significantly raised the erythrocytic selenium concentration.;The third study helped us develop a simple, non-invasive method to detect high exposures to selenium, by analyzing the expired air. A kinetic model of selenium elimination from the respiratory tract was also proposed. |
