| This thesis addresses the topic of chiral stationary phases with multiple interaction centers. Chirality deals with the asymmetry of an entity. In chemistry, this concept explains why an object and its mirror image are non-superimposable. This very property has been used in the synthesis of chiral stationary phases for chromatographic separations. Both gas and liquid chromatography columns have been researched in this review.; These types of phases were designed specifically to separate enantiomeric compounds. William Pirkle was the pioneer in the synthesis of Chiral Stationary Phases (CSPs) and Dalgliesh proposed the theoretical model by which the separations occurred. The primary focus of this review is the effect of the presence of an extra chiral center on a chiral stationary phase. It has been concluded that, the presence of an extra chiral center does improve separation of certain enantiomers when compared to conventional stationary phases. |
