Chemistry and radiochemistry of rhenium and technetium for applications as potential radiopharmaceuticals

This thesis investigates the synthesis and characterization of Re(III) and Re(V)oxo Schiff base complexes with tertiary phosphines. The complexes are formed by reacting trans-[ReVO(X)L] + with tertiary phosphine of the type PR3. The result of these reactions yielded two different complexes, the mono cis PR3 or the bis trans PR3. It was noticed that the yielded complex was dependent on both the type of ligand and phosphine. When the ligand was acac2pn the result was always a complex of the form cis-[ReVO(PR3)(acac 2pn)]+.;A series of reactions with monodentate nucleophiles was investigated in an attempt to better understand the rearrangement versus reduction phenomenon that was seen with tertiary phosphines. The reactions involved starting with the Re(V)oxo complex and reacting it with either NCS- or CN-. It was noticed that regardless of the nucleophile or ligand the rearranged product analogous to the form cis-[Re VO(X)(L)] was yielded.;A radiolabeling experiment with technetium was done with the Schiff base ligand acac2pn and tertiary phosphines. The results suggest that the complex formed is most likely of the form, trans-[Tc III(PR3)2(acac2pn)]+. This is based on comparing the data to the Re(III) and Re(V)oxo phosphine complexes and to trans-[TcIII(PR3) 2(acac2en)]+.