| Atopic Dermatitis (AD) is a chronic inflammatory skin disease characterized by a high rate of colonization by Staphylococcus aureus , which may contribute to the pathology and chronicity of AD. S. aureus isolates belonging to CC45 accounted for 26% of the AD isolates, in contrast to asymptomatic nasal carriage, in which CC30 is predominant. PFGE profile comparisons revealed similarities between AD isolates belonging to CC45 and CC1 with CMRSA-1/USA600 and CA-MRSA, USA400 or CA-MSSA, MSSA476 strains, respectively. The ST1 isolates possessed the SCC476 element, and enterotoxins SEB and SEC had a strong association with CC1 and CC45 groups. Unique variations of virulence gene compositions within the nuSabeta genomic island were frequently found. Furthermore, AD patients remained colonized or became colonized by the same strain despite antimicrobial and anti-inflammatory therapeutic treatment. These findings provide key advances that will lead to better management and treatment strategies for AD. |
