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Synthetic studies toward the total synthesis of fostriecin and some analogs

Posted on:2007-10-04Degree:Ph.DType:Thesis
University:Michigan State UniversityCandidate:Phillips, Glenn WaltonFull Text:PDF
GTID:2441390005473069Subject:Chemistry
Abstract/Summary:
The development of a novel aldol reaction between 2-alkynals and methyl [(4R, 5S)-1,5-dimethyl-4-phenyl-2-imidazolidinone] methylene tetracarbonyl chromium (0) and its enantiomer, has provided a unique approach to the total synthesis of fostriecin; an antitumour agent. The synthetic strategy outlined for this natural product is a convergent one and involves a lactone, diene and triol fragment. All three fragments have been successfully prepared in high yields and a formal synthesis of fostriecin has also been accomplished.
Keywords/Search Tags:Synthesis, Fostriecin
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