Clinical Observation Of Cangfudaotan Decoction Combined With Metformin In The Treatment Of Phlegm-damp Obesity With Dyslipidemia

Objective:This subject is to observe the effects of Cangfu Daotan Decoction combined with metformin on glucose and lipid metabolism,islet function and BMI in patients with phlegm-dampness obesity complicated with dyslipidemia,and explain the mechanism of action of drugs,discover safe and effective ways to treat the disease.Methods:This subject uses randomized controlled research method,72 patients who met the inclusion criteria were randomized to the treatment group and the control group.The course of treatment is 12 weeks,the observations included efficacy indicators(BMI,waist circumference,blood lipids,HOMA-IR,HOMA-IAI,TCM syndrome score)and safety indicators(liver and kidney function,blood routine),to evaluate the clinical efficacy and safety of Cangfu Daotan Decoction.Results:1.BMI After 12 weeks of treatment,the BMI of the treatment group and the control group all decreased,the difference was statistically significant(P<0.05),and the BMI of the treatment group decreased more than the control group.1.Waist circumference After 12 weeks,the waist circumference of the treatment group and the control group decreased,the difference was statistically significant(P<0.05).And there was a statistically significant difference between the two groups(P<0.05).2.Blood lipids Compared with before treatment,the blood lipids of the two groups were decreased,TG,TC,LDL-C decreased(P<0.05),HDL-C levels increased(P<0.05),the difference was statistically significant,and the treatment group The downward trend of TG is more obvious.There was no significant difference between the two groups after TC and LDL-C treatment for 12 weeks(P>0.05).There was significant difference between the two groups after HDL-C treatment for 12 weeks(P<0.05).3.HOMA-IR,HOMA-IAIBoth the treatment group and the control group could reduce HOMA-IR level and increase HOMA-IAI level(P<0.05),and the difference was statistically significant.4.TCM syndrome score There was no significant difference in TCM syndrome scores between the two groups before treatment and 6 weeks after treatment(P>0.05).There were statistical differences in TCM syndrome scores between the two groups before treatment and 6weeks after treatment and 12 weeks after treatment.Academic significance(P<0.05).5.Total clinical curative effect After 12 weeks of treatment,the treatment group was cured in 2 cases,markedly effective in 14 cases,effective in 19 cases,and ineffective in 1 case.The total effective rate was 97.22%.In the control group,0 cases were cured,18 cases were effective,16 cases were effective,and 2 cases were ineffective.The total effective rate is 94.44%.The chi-square test showed no significant difference in clinical efficacy between the two groups(P=0.555).There was a statistically significant difference in TCM syndrome scores between the treatment group and the control group after 12 weeks of treatment(P=0.053).6.Safety evaluation After 12 weeks of treatment,there were no adverse events in the treatment group and the control group,indicating that both groups have good safety.Conclusion:Cangfu Daotan Decoction combined with metformin can alleviate the weight of patients with phlegm-dampness obesity and dyslipidemia,reduce their waist circumference,effectively improve lipid metabolism and insulin resistance,and improve clinical symptoms.The curative effect is better than metformin alone.