| Objective:Study 1:Through the network meta-analysis to evaluate the effect of different traditional exercise methods on mild cognitive impairment,and provide the best choice for later experiments.Study 2:Based on the results of Study 1,choose the best intervention method Ba Duan Jin,scientifically evaluate the clinical efficacy of Ba Duan Jin intervention in the cognitive impairment of middle-aged and young adults,and provide a simple and feasible method for the intervention of cognitive impairment of the middle-aged and young adults.method.Methods:Study 1:Computer searched CNKI,Wanfang,Weipu,Web of Science,Pubmed,Cochrane databases to collect randomized controlled trials of traditional exercise skills+general exercise or blank control treatment for mild cognitive impairment.Two researchers independently screened the literature,extracted data and evaluated the risk of bias in the study,and used R gemtc package for data analysis.Study 2:Based on the results of network meta-analysis,choose Ba Duan Jin as the intervention method and use the random control method.According to the sample size calculation,the sample size of each group was 34,and the patients were divided into a treatment group and a control group according to a random number table.The test group was Ba Duan Jin treatment combined with health education,and the control group was health education,applying simple mental state.Assessment Scale(MMSE),Dementia Syndrome Element Scale(PES-D),Hamilton Depression Scale(HAMD),Hamilton Anxiety Scale(HAMA),World Health Organization Quality of Life Scale Short Form((WHOQOL-BREF)During the intervention process,0,2,4,and 6 months were used as the summary points for scoring.The software SPSS 25.0 was used to analyze the data and the two-sided test was used for statistical testing.If the P value?0.05,the difference was statistically significant.The measurement data conforms to the normal distribution using the paired sample t test,and the non-parametric distribution uses the two sets of related sample non-parametric tests;the measurement data between the two groups compares to the normal distribution using the independent sample t test,and does not meet the normal distribution.Two sets of independent sample nonparametric tests.Repeated measurement analysis of variance was used to observe the outcome of changes at different points in time.Analyze the impact of Ba Duan Jin on the cognitive function of patients with mild cognitive impairment and the difference between different TCM syndromes,and evaluate their clinical efficacy.Results:Study 1:The network meta-analysis included a total of 7 RCTs,including 1001 patients with mild cognitive impairment,involving Ba Duan Jin,Tai Chi,general exercise or brisk walking,blank control or health education.The analysis results show that the Baduanjin group has the strongest effect,followed by the Taijiquan group,and the regular exercise brisk walking group again.All three have higher efficacy than the blank or health education group.Study 2:The use of Baduanjin to intervene in middle-aged and young people's cognitive impairment,the test group was Baduanjin treatment combined with health education,and the control group was health education.The results are analyzed as follows:1.Results of efficacy evaluation:After 6 months of intervention,0 cases were clinically controlled in the experimental group(Baduanjin United Health Education),8 cases were significantly improved,11 cases were improved,12 cases were ineffective,and the total effective rate was 61.29%;the control group(health Education)0 cases of clinical control,1 case improved significantly.0 cases improved,29 cases ineffective,the total effective rate was 3.33%;the overall efficacy of the two groups was tested and the difference was statistically significant(P<0.05).Better than pure health education.2.MMSE scoring results:the difference between the MMSE scores of the test group and the control group at the end of June was statistically significant(P<0.05);the MMSE scores of the test group at the end of 2,4,and 6 months were compared with 0 months,and the differences were statistically significant(P<0.05);indicating that Ba Duan Jin joint health education can improve patients' cognitive function,and the effect is better than the control group.3.Results of PES-D scores:There was a statistically significant difference between the efficacy scores of TCM syndrome patients at the end of June and 0 months in the experimental group(P<0.05),indicating that Ba Duan Jin has therapeutic effects on patients with various syndromes.There was a statistically significant difference in the MMSE scores and psychological field scores of patients with kidney deficiency syndrome in the experimental group and the control group at the end of June(P<0.05),indicating that Ba Duanjin's cognitive improvement was more obvious in patients with kidney deficiency.4.Results of HAMD score:There was a statistically significant difference between the experimental group and the control group at the end of June(P<0.05);the HAMD scores of the experimental group at the end of June,April,and June were compared with the month of 0,and the differences were statistically significant(P<0.05).It shows that the joint health education of Baduanjin can improve the patients' depression status,and it has more obvious effect than simple health education.5.HAMA score results:There was a statistically significant difference in the HAMA score between the test group and the control group at the end of June(P<0.05):the HAMA scores of the test group at the end of June,April,and June were compared with the month of 0,and the differences were statistically significant(P<0.05).It shows that the joint health education of Baduanjin can improve the anxiety state of patients,and it has more obvious effect than simple health education.6.WHOQOL-BREF score results:At the end of February:Compared with 0 months in the experimental group,the differences in the physiological field,psychological field,and social relationship field were statistically significant(P<0.05).At the end of April:Compared with 0 month in the experimental group,the differences in physiological field,psychological field,social relationship field,Q1and Q2 were statistically significant(P<0.05).At the end of June:Compared with the control group,the difference between the psychological field and the social relationship field was statistically significant(P<0.05).Compared with 0 month in the experimental group,the differences in physiological field,psychological field,social relationship field,Q1 and Q2 were statistically significant(P<0.05).It shows that the joint health education of Baduanjin can improve the quality of life of patients,and it has more obvious effect than simple health education.Conclusion:Study 1:Network meta-analysis results showed that the Ba Duan Jin group had the strongest effect,followed by the Tai Chi group,followed by the regular exercise brisk walking group,and all three had higher efficacy than the blank or health education group.Study 2:The overall efficacy of Baduanjin combined health education intervention in middle-aged and young-aged cognitive impairment is better than simple health education,which can improve the cognitive function of patients with middle-aged and young-aged cognitive impairment,reduce depression and anxiety,and effectively improve psychological The quality of life in the field of social relations is conducive to patients to maintain mental health and reduce social burden. |
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