| ObjectiveUsing complex network technology to analyze the clinical medication rule of Professor Huang Shijing's treatment of ischemic leukoencephalopathy in traditional Chinese medicine,and summarize his treatment ideas and experience.Through the clinical observation of his self-made Huangjing Jiannao formula in the treatment of ischemic leukoencephalopathy combined with chronic insomnia,its efficacy and safety were preliminarily evaluated,providing a new treatment formula for the clinical treatment of ischemic leukoencephalopathy combined with chronic insomnia,and laying a foundation for further in-depth study and improvement of the clinical efficacy of the disease.MethodsThrough sorting out the case data of Professor Huang's treatment of ischemic leukoencephalopathy from 2018 to 2019,loading the data with the complex relationship analysis software of traditional Chinese medicine,generating network diagram according to the conditions,and exploring the law of medication.From December 2018 to January 2020,the patients with ischemic leukoencephalopathy and chronic insomnia who met the inclusion criteria were selected from the outpatient department of geriatrics department of Guang'anmen Hospital of Chinese Academy of traditional Chinese medicine,and were treated for 12 weeks on the basis of Huangjing Jiannao formula.The PSQI and TCM symptom score were measured at the time of enrollment and at the 4th,8th and 12th weeks after treatment respectively.The SPIEGEL,MOCA and MMSE were estimated at the time of enrollment and at the 12th weeks after treatment respectively.At the same time,routine indexes such as biochemistry and electrocardiogram were monitored before and after treatment.After the treatment,SPSS 20.0 was used to analyze all the data and evaluate the efficacy and safety of the drug.Results1.According to the generated network diagram,the core prescription,commonly used compatibility,drug frequency and compatibility frequency of Professor Huang in the treatment of ischemic leukoencephalopathy are obtained,which provides data explanation for the understanding of the pathogenesis of "Xu Qi Liu Zhi",the treatment proposal of Peiyuan Tongzhi,and the treatment of this disease with Huangjing Jiannao formula.2.PSQI score:The total score and each item's score of the PSQI of the subjects before treatment,at the 4th,8th and 12th weeks of treatment were all P<0.05,indicating that the sleep quality,sleep latency,sleep time,sleep efficiency,sleep disorder and daytime dysfunction of the subjects after treatment were improved compared with those before treatment.Each item's score were compared in each two different periods,it was found that the adjusted p value was more than 0.05 when the 8th week was compared with the 4th week,indicating that 12 weeks of treatment could improve the sleep condition of the subjects better than 8 weeks of treatment.3.SPIEGEL score:The total score of SPIEGEL before treatment was compared with that at the 12th week of treatment,P value<0.05,indicating that the total score of SPIEGEL at the 12th week of treatment was lower than that before treatment.Each item's score of SPIEGEL before treatment was compared with that at the 12th week of treatment,P value<0.05,indicating that the sleep latency,total sleep time,times of waking up at night,sleep depth,situation of dreaming at night and feeling after waking at the 12th week of treatment were improved compared with those before treatment.4.Score of TCM symptom integral table:The total scores of TCM symptom integral table was compared in each two different periods,P value<0.05,indicating that the total score of TCM symptom integral table of subjects after treatment was lower than that before treatment.In addition to sweating and dry mouth,each item's score of TCM symptom integral table was all P<0.05,indicating that there were differences in the each item's score of TCM symptom integral table in different periods of treatment except for sweating and dry mouth.The score of sleep related symptoms was compared in each two different periods,it was found that 12 weeks of treatment could improve the sleep condition of the subjects better than 8 weeks of treatment.5.MoCA score:Compared with the total score of MoCA before treatment and at the 12th week of treatment,P value<0.05,indicating that the total score of MoCA at the 12th week of treatment was higher than that before treatment.Compared with each item's score of MoCA before treatment and at the 12th week of treatment,except for orientation,P value was<0.05,indicating that the scores of visual space and executive function,naming,attention,language,ion,and delayed recall function of the subjects at the 12th week of treatment were all increased compared with those before treatment.6.MMSE score:Compared with the total score of MMSE before treatment and the 12th week of treatment,P value is less than 0.05,indicating that the total score of MMSE in the 12th week of treatment was higher than that before treatment.In the aspects of attention and calculation ability,recall ability,retelling,structure function,the scores were compared before and after treatment,P<0.05,indicating that the scores of the attention and calculation ability,recall ability,retelling,structure function of the subjects in the 12th week of treatment were increased than those before treatment.7.According to PSQI,the total effective rate was 90.9%.8.There was no adverse reaction in all subjects,and no obvious abnormality in safety index before and after treatment.Conclusion1.Huangjing Jiannao formula can effectively improve the sleep condition and TCM Syndromes of patients with ischemic leukoencephalopathy and chronic insomnia.2.Compared with 8 weeks,12 weeks treatment course can better improve the insomnia of patients with ischemic leukoencephalopathy and chronic insomnia.3.Huangjing Jiannao formula can improve the cognitive function of patients with ischemic leukoencephalopathy and chronic insomnia.4.Huangjing Jiannao formula has good safety in the treatment of ischemic leukoencephalopathy combined with chronic insomnia. |
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