Study On The Difference Of Homocysteine ??levels In Patients With TCM Deficiency Syndrome In Acute Ischemic Stroke

The purpose and significance:In this study,the level of homocysteine and the related blood indexes of the two groups were detected by completing the TCM syndrome differentiation and classification of the acute stage of ischemic stroke,and the score of neurological deficit was recorded,To compare the difference of homocysteine level between the two groups in order to clarify the evaluation effect of homocysteine on the patients with deficiency and excess syndrome in the acute stage of ischemic stroke,and to find the basis for evaluating the clinical effect of the treatment of ischemic stroke.To record the related indexes of blood test in patients with deficiency and excess syndrome of traditional Chinese medicine in the acute stage of ischemic stroke,to make statistical analysis and Research on the correlation between the level of homocysteine and these indexes,and to observe the relationship between homocysteine and the related evaluation indexes of ischemic stroke,In order to clarify the role of homocysteine in the network mechanism of ischemic stroke.Methods:In this study,90 patients with acute stage of ischemic stroke were included in the study by case-control method,including 45 cases in the positive(phlegm,heat,Fu and solid)group,45 cases in the deficiency(yin deficiency and wind movement)group,and 2 graduate students were engaged in TCM syndrome differentiation and typing of ischemic patients who met the inclusion criteria.In the morning after admission,the blood samples of elbow vein were taken from the patients on an empty stomach for blood test.The serum homocysteine and other related blood test indexes were detected by fluorescence partial positive immunoassay.The age,sex,smoking and drinking history,hypertension and sugar were recorded Through statistical analysis,the difference of homocysteine level between the patients with deficiency and excess syndrome of traditional Chinese medicine in the acute stage of ischemic stroke was studied.Results1.According to the inclusion criteria,90 cases were included in this study,and 90 cases completed clinical information collection and index detection.2.General information:there was no significant difference in gender,history of hypertension,history of diabetes and history of hyperlipidemia between the two groups(P>0.05),which was comparable;there was significant difference in age,drinking and smoking history(P<0.05).3.There was no significant difference in blood routine,biochemical and coagulation items among the groups(P>0.05).4.Correlation analysis between Hcy and related risk factors:Hey in the plasma of acute ischemic stroke was positively correlated with HGB,GGT and crea,and negatively correlated with APTT,while Hey was not correlated with other indicators(P>0.05).But its specific mechanism needs further experimental study.5.Pearson correlation analysis of plasma Hey and neurological deficit(severity):there was a significant correlation between plasma Hey and neurological deficit score(P<0.001).The results showed that the higher the plasma Hey value deviated from the normal value,the higher the severity of ischemic stroke,which was consistent with the previous research results.6.The difference of plasma Hcy between the two groups:The results showed that there was significant difference between the two groups in Hcy level(P<0.05),and the difference was statistically significant(P<0.05).Conclusion1.In the acute stage of ischemic stroke,there is a significant difference in Hey level between the syndrome type of phlegm heat and Fu and the syndrome type of yin deficiency and wind movement,and the syndrome type of phlegm heat and Fu is more than the syndrome type of yin deficiency and wind movement,which indicates that the Hey level of the syndrome type of phlegm heat and Fu is higher than that of the syndrome type of yin deficiency and wind movement,and the disease severity of the syndrome type of phlegm heat and Fu is higher,which needs to be diagnosed and treated as soon as possible,indicating that the plasma Hey level can be used as ischemic stroke One of the objective indexes of TCM syndrome differentiation and classification in the middle and acute stage is helpful to improve the objectification and microcosmic of TCM syndrome differentiation of ischemic stroke and provide more theoretical basis for the treatment of ischemic stroke with TCM.2.It was preliminarily determined that Hey was positively correlated with HGB,GGT and crea,and negatively correlated with APTT.