| Objective:Epigastric pain syndrome(EPS),as one of the main subtypes of functional dyspepsia(FD),has the characteristics of high prevalence,complex symptoms,and recurrent conditions,which brings great physical and mental illness to patients.So how to cure this disease better and faster has been paid more and more attention by clinical doctors.However,because the pathogenesis of EPS has not yet been fully elucidated,Western medicine still treats the disease symptomatically and improves the symptoms.The clinical effect is not very satisfactory.Patients often take effect when taking the medicine,and it is very easy to relapse after stopping the medicine.Traditional Chinese medicine treats this disease with little side effects,high safety,and low recurrence rate.Modern Chinese medicine practitioners have also accumulated a large amount of clinical experience for traditional Chinese medicine treatment of this disease.Based on this,this study is based on academician Dong Jianhua’s theory of qi and blood in the treatment of spleen and stomach disease,and aims at college students.By observing the efficacy and safety of Biling Weitong Granules for functional dyspepsia epigastric pain syndrome qi stagnation and blood stasis syndrome,evaluation The role of regulating qi and activating blood in the treatment of this disease,with a view to providing evidence-based basis for the clinical promotion of this method.Methods:This study selected Eighty EPS college students with qi stagnation and blood stasis syndrome from March 2018 to October 2019 at the Oriental Hospital of Beijing University of Chinese Medicine,Xiyuan Hospital of China Academy of Chinese Medical Sciences,Shandong Provincial Hospital of Traditional Chinese Medicine,Hebei Provincial Hospital of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine First Affiliated Hospital,Tianjin Traditional Chinese Medicine Second Affiliated Hospital,they were randomly divided into a placebo group and a treatment group,with 40 cases in each group.The placebo group was given oral treatment of placebo,and The treatment group was given oral treatment of Biling Weitong Granules.The drug was continuously administered for 6 weeks and observed for 2 weeks,and then the test was ended.Record and evaluate the total score of upper abdominal pain symptoms before and after treatment,the degree of seizures,the frequency of attacks,the disappearance rate of upper abdominal pain symptoms,the EPS symptom rating scale,the functional dyspepsia quality of life scale(FDDQL),the use rate of aluminum magnesium carbonate tablets,and the amount used,Safety indicators and adverse events and incidences during clinical research.SPSS 20.0 software was used for statistical analysis of the research data.Results:1.Comparison of upper abdominal pain relief rates:34 patients in the treatment group had a total upper abdominal pain score that was 50%or more lower than before treatment,and the relief rate of upper abdominal pain symptoms was 87.18%.the placebo group had 7 patients with a relief rate of 17.95%.The relief rate of upper abdominal pain in the treatment group was significantly higher than that in the placebo group(P=0.00<0.05).2.Comparison of the severity of upper abdominal pain:The severity of upper abdominal pain began to differ significantly between the two groups after 2 weeks of treatment,and the symptoms of upper abdominal pain in the treatment group were significantly lower than those in the placebo group(P<0.05).3.Comparison of the frequency of upper abdominal pain:The frequency of upper abdominal pain began to differ significantly between the two groups after 3 weeks of treatment,and the frequency of upper abdominal pain in the treatment group was significantly lower than in the placebo group(P<0.05).4.Comparison of the disappearance rate of upper abdominal pain symptoms:The number of disappearance of upper abdominal pain symptoms in the treatment group was 31,and the disappearance rate was 79.49%.The number of disappearance of upper abdominal pain symptoms in the placebo group was 7 and the disappearance rate was 17.95%.The rate of disappearance of upper abdominal pain in the treatment group was significantly higher than that in the placebo group(P=0.00<0.05).5.Comparison of clinical efficacy of EPS:7 cases of clinical healing in the treatment group,20 cases of marked effect,11 cases of effectiveness,1 cases of ineffectiveness,and the total effective rate of improvement of clinical symptoms was 97.44%;1 case of clinical healing in the placebo group,1 case was markedly effective,10 cases were effective Cases,27 cases were invalid,the total effective rate was 30.77%.The total effective rate of improving the clinical symptoms of EPS in the treatment group was significantly higher than that in the placebo group(P=0.00<0.05).6.Comparison of functional dyspepsia quality of life scale(FDDQL)scores:The overall quality of life of the patients in the treatment group was significantly improved compared with the placebo group,and there was a significant improvement starting 4 weeks after taking the drug(P<0.05).Patients in the treatment group had significantly higher quality of life in the 8 areas of daily activities,anxiety,diet,sleep,discomfort,health feelings,disease control,and stress(P<0.05).7.Comparison of the use rate and amount of aluminum magnesium carbonate tablets:the use rate of the treatment group was 15.38%,and the use rate of the placebo group was 28.20%.There was no significant difference in the use rate of aluminum magnesium carbonate tablets between the two groups(P=0.17>0.05).Among the people who used aluminum magnesium carbonate tablets,the treatment group used(7.83 ± 7.76)tablets per person,and the placebo group used(14.18±7.78)tablets per person.There was no significant difference between the two groups(P=0.13>0.05).8.Comparison of safety indicators and incidence of adverse events:There were no significant abnormalities in safety indicators in the treatment group.There were 4 cases of mild adverse events in each of the two groups(1 case of diarrhea in each group),no serious adverse events occurred,and there was no prominent difference in the incidence of adverse events(P>0.05).Adverse events disappeared after follow-up observation.Conclusion:1.The method of regulating qi and activating blood can effectively alleviate the clinical symptoms of EPS college students with qi stagnation and blood stasis syndrome,reduce the onset degree,frequency and incidence of upper abdominal pain symptoms,significantly improve the quality of life of patients.2.Biling Weitong Granules,a representative prescription of regulating qi and activating blood circulation,has no serious adverse reactions and is safe and worthy of further promotion. |
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