The Law Of Syndrome And Treatment Of Gouty Arthritis Combined With Hyperlipidemia

Objective: To explore the distribution characteristics and medication rules of gouty arthritis(GA)combined with hyperlipidemia in order to provide more reference and reference for TCM syndrome differentiation and treatment.Material and method:Based on the study of inpatients from the Department of Rheumatology and Immunology of the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine(October 2018 to September 2019),the cases were screened strictly in accordance with the inclusion and exclusion criteria.A database was established using SPSS 22.0,and SPSS Modeler 14.2 association rule Apriori.The software performs data mining,analyzes the distribution characteristics of gouty arthritis with hyperlipidemia,and explores the rules of medication.Results:1.In this study,198 cases were collected,the male to female ratio was 10.64: 1;the average age was 50.06 ± 15.006 years.2.Syndrome distribution(sorted by composition ratio): damp-heat and obstruction syndrome(44.94%)> damp-heat and obstruction syndrome with blood stasis syndrome(40.40%)> phlegm-stasis and obstruction syndrome(5.05%)> cold-dampness syndrome and blood-stasis syndrome(3.03%)> Heat and dampness obstruction syndrome(2.53%)=Stagnation and heat blockage syndrome(2.53%)> Spleen deficiency dampness syndrome(1.52%).3.This study collected 207 prescriptions,involving 209 flavors of Chinese medicine,medication frequency 2857 times,and 19 drug categories.39 traditional Chinese medicines with a frequency of ?20 such as Cangzhu and Huangbai are common drugs for treating gouty arthritis with hyperlipidemia;Antipyretics,tonics,diuretic and dampness drugs,and blood circulation and blood stasis drugs are the main drug categories for the treatment of this disease.4.Cluster analysis was performed on 39 Chinese medicines with a dosage of ?20,and a total of 6 clustered drug groups were obtained:Class1,Cangzhu,Huangbai,Achyranthes bidentata,Yiyiren,Tufuling,Bixie,Zexie Angelica,Chuanxiong,Yinchen,Polygonum-cuspidatum,Duhuo,Fangji,Qianghuo;Class2,Chisha o,Jinyinhua;Class3,Baizhu,Huangqi,Shanyurou,Shanyao,Danshen;Class4,Chaihu,Guizhi,Ganca o,Baishao,Huangqin,Weilingxian,Shancigu,Cheqianzi;Class5,Mudanpi,Rendongteng,Shengdih uang,Zhimu;Class6,Taoren,Honghua,Banxia,Chenpi,Fuling.5.Correlation analysis was performed on 209 flavors of traditional Chinese medicine,and a total of 117 association rules for drug pairs and medicine groups were obtained.Among them,the highest support for Huangbai + Cangzhu was 54.655%.Conclusion:1.In this study,the correlation between gender and age in patients with gouty arthritis and hyperlipidemia was found to be frequent in male patients aged 31-70,which is consistent with the characteristics of epidemiological research.2.According to the syndrome distribution of gouty arthritis with hyperlipidemia,the disease is mainly based on evidence,supplemented by deficiency.Among them,the dampness-heat dysfunction syndrome accounted for the highest proportion,so the treatment criteria were mostly heat-clearing and dampness-reducing,and both righting and tonifying.3.Studies show that high-frequency drugs have:Huangbai,Cangzhu,Niuxi,Yiyiren,Bixie,Zexie,Tufuling and so on,Commonly used drug pairs:Cangzhu,Huangbai;Huangbai,Achyranthes-bidentata;Cangzhu,Yiyiren.