Related Research On NLR, PLR And DLEAD, As Well As TCM Syndrome Distribution And Efficacy Evaluation

Objective: To observe the clinical symptoms of patients with type 2 diabetes mellitus complicated with lower extremity arterial disease,analyze the relevant indexes,obtain the relevant factors and the distribution of traditional Chinese medicine syndromes of type 2 diabetes mellitus complicated with lower extremity arterial disease,explore the correlation between NLR,PLR and the onset of DLEAD,and conduct metaanalysis on RCT literature of TCM therapy for DLAD,so as to provide evidence-based medical evidence for the treatment of the disease.Materials and Methods: Paper 1:60 patients with DLEAD were randomly selected from the electronic medical record system of the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine as the observation group and 60 patients without DLEAD as the control group.The age,sex,course of disease,BMI,fasting blood glucose,glycosylated hemoglobin,TG,CHOL,HDL-C,LDL-C of the two groups were compared.The incidence of common T2 DM complications such as DR,DN and DPN were recorded.The syndrome types of patients were analyzed and statistically analyzed according to the data on admission.SPSS 22.0 software was used for statistical analysis of the data.Paper 2: Searched CNKI,Wanfang Data and Vip database with the key words of "traditional Chinese medicine therapy","combination of Chinese and western medicine","DLEAD","Lower extremity arterial disease of diabetes patients" and "diabetes complicated with lower limb arterial disease",reviewed relevant clinical RCT studies.Meta analysis was carried out on the included literatures with Rev.Mans5.3.Results: Paper 1: 1.The onset of DLEAD is related to age,course of disease,FPG,Hb A1 c,LDL-C,e GFR,NLR,PLR,accompanying DPN,accompanying DN,accompanying DR,accompanying coronary heart disease and accompanying hypertension.Age is an independent risk factor for the onset of DLEAD.2.NLR and PLR are positively correlated with the incidence of DLAD.ROC curve indicates that they can predict the incidence of DLAD,but their efficacy may be average.3.The majority of patients with DLEAD are qi deficiency syndrome,yin deficiency syndrome,blood stasis syndrome and dryness-heat syndrome,and their pathological characteristics are deficiency and excess combined with deficiency and excess.The key pathogenesis can be summarized as "deficiency","heat" and "blood stasis".The disease is located in spleen,lung,liver and kidney.4.In the early stage of DLEAD,it was mostly based on the deficiency of both qi and yin combined with dryness-heat.Qi deficiency was unable to promote blood circulation,yin deficiency was unable to nourish blood vessels,and dryness-heat decocted body fluid.On this basis,blood circulation was gradually impeded,blood stasis blocked collaterals,and arteries were damaged.That is,the deficiency of both qi and yin combined with dryness-heat is the basis and blood stasis vein is the standard.Paper 2: 1.TCM therapy can improve the clinical effective rate of DLEAD therapy;2.TCM therapy can significantly improve the blood sugar,blood lipid,hemorheology,inflammatory factors,ABI and dorsalis pedis artery pulsation of patients.3.The TCM therapy mostly adopts the method of invigorating qi and promoting blood circulation,dispersing blood stasis and dredging collateral,can effectively improve the symptoms of patients with DLEAD;4.TCM therapy has high safety and no serious adverse reactions.5.The combination of internal and external treatment of traditional Chinese medicine has the best effect on DLEAD,followed by internal treatment of traditional Chinese medicine and external treatment of traditional Chinese medicine.Conclusion: 1.The onset of DLEAD is related to age,course of disease,FPG,Hb A1 c,LDL-C,e GFR,NLR,PLR,accompanying DPN,accompanying DN,accompanying DR,accompanying coronary heart disease and accompanying hypertension.Age is an independent risk factor for the onset of DLEAD.2.NLR and PLR are positively correlated with the incidence of DLAD.ROC curve indicates that they can predict the incidence of DLAD,but their efficacy may be average.3.The majority of patients with DLAD are Qi deficiency syndrome,Yin deficiency syndrome,blood stasis syndrome and dryness-heat syndrome,and their pathological characteristics are deficiency and excess combined with deficiency and excess.DLEAD is based on deficiency of both qi and yin combined with dryness-heat and blood stasis vein.Blood stasis runs through the occurrence and development of DLEAD,and its proportion gradually increases as the disease progresses.The disease is located in spleen,lung,liver and kidney.4.Traditional Chinese medicine therapy can improve the clinical effective rate of DLEAD treatment,and significantly improve the blood sugar,blood lipid,hemorheology,inflammatory factors,ABI and dorsalis pedis artery pulsation of patients.5.Traditional Chinese medicine therapy mostly adopts legislation of invigorating qi and promoting blood circulation,removing blood stasis and dredging collaterals to treat DLEAD.The combination of internal and external treatment of traditional Chinese medicine has the best effect,followed by internal treatment of traditional Chinese medicine and external treatment of traditional Chinese medicine.