Clinical Study On The Treatment Of Vascular Dementia Of Kidney Yin Deficiency And Blood Stasis Type By Zishen Huoxue Recipe

Objective: Study the efficacy of Zishenhuoxue Prescription in the treatment of vascular dementia(VD)of kidney-yin deficiency and blood stasis type,and thus explore the treatment of VD of kidney-yin deficiency and blood stasis type.Methods: Inclusion of 60 VD patients from the inpatient and outpatient departments of the Affiliated Hospital of Hunan Academy of Chinese Medicine,western medicine diagnosis using the United States mental disorders diagnosis and statistical manual standards and the National Institute of Neurology and Stroke/Swiss International Conference on Neuroscience Research standards,TCM syndrome diagnosis using the "vascular dementia syndrome differentiation scale" and "Chinese medicine new drug clinical research guidelines(trial)" on the treatment of senile dementia clinical research guidelines.The degree and efficacy of dementia were assessed using Mini Clinical Dementia Rating Scale(CDR),Mental State Examination(MMSE),Activity of Daily Living(ADL),and a chinese medicine syndrome rating scale.The patients were divided into Chinese medicine group and western medicine group.The western medicine group took the donepezil hydrochloride tablets,and the traditional Chinese medicine group took the oral Zishenhuoxue prescription.Cognitive function,daily life ability,TCM syndrome scores were evaluated,and three major routine,liver and kidney function,coagulation function and electrocardiogram were tested before the treatment,after 8 and 12 weeks of the treatment to evaluate the efficacy and safety of this study.Results: There was no significant difference in sex,age,dementia degree,education degree,past medical history and scores before the treatment among the patients in Chinese medicine group and western medicine group(P>0.05).After 8 weeks,the change of MMSE scores of traditional Chinesemedicine group and western medicine group were 1.43±0.77 and 1.36±0.99,there was no significant difference between the two groups(P>0.05).After8 weeks,the change of ADL scores of Chinese medicine group and western medicine group were 3.57±2.18 and 3.43±1.71,there was no significant difference between the two groups(P>0.05).After 8 weeks,the change of scores of TCM syndromes in Chinese medicine group and western medicine group were 10.50±4.45 and 5.14±3.66,the Chinese medicine group was significantly better than the western medicine group(P<0.01).After 12 weeks,the change of MMSE scores of Chinese medicine group and western medicine group were 3.93±2.02 and 2.96±1.48,the Chinese medicine group had a trend of superiority over the western medicine group(P=0.061).After12 weeks,the change of ADL scores of the Chinese medicine group and the western medicine group were 7.43±4.45 and 6.04±3.17,the Chinese medicine group had a trend of superiority over the western medicine group(P=0.077).After 12 weeks,the change of the scores of TCM syndromes in Chinese medicine group and western medicine group were 17.53±5.89 and9.68±6.15,and the Chinese medicine group was significantly better than the western medicine group(P<0.01).Conclusion: Zishenhuoxue prescription is safe in the treatment of VD.Both Zishenhuoxue prescription and Donepezil hydrochloride tablets may improve the cognitive function,daily life ability and TCM syndrome score of the patients of VD of kidney-yin deficiency and blood stasis type.While the Zishenhuoxue prescription is superior to the Donepezil hydrochloride tablets in improving TCM syndrome score.