To Explore The Mechanism Of Sevoflurane On The Cognitive Function Of The Elderly From The NMDA Receptor (ERK) 1/2 And P38MAPK Pathway

Postoperative cognitive dysfunction(POCD)is a common complication of central nervous system after general anesthesia,which can reduce the quality of life and increase disability and mortality.But its etiology and pathogenesis have not been elucidated.Some related studies have shown that sevoflurane anesthesia may lead to postoperative cognitive dysfunction in elderly patients with concentration.NMDA receptor plays an important part in learning and memory.In mature neurons,a variety of factors by changing NR2 A and NR2 B expression of NMDA receptor affect signaling pathways(ERK)1/2,P38 MAPK conduction,causing neurotoxic effect,thus influence cognitive function.This study mainly discusses the 3% sevoflurane anesthesia on cognitive function in elderly and NR2 A and NR2 B expression of NMDA receptor and its signal pathway(ERK 1/2),the influence of P38 MAPK,resolve whether sevoflurane on cognitive function in elderly dose dependent damage and its molecular mechanism.Through our research of rats after 3% sevoflurane inhalation of behavior change,molecular biological mechanism,and the exposed to different concentrations of hippocampal neurons in vitro under the sevoflurane,find out the concentration range of sevoflurane inhalation can lead to cognitive impairment for elderly and eventually to the clinical significance.In conclusion,after inhalation of sevoflurane,the cognitive function of senile SD rats was impaired,and the spatial cognitive ability decreased,and the conduction of signal pathway(ERK)1/2 and P38 MAPK was affected.