Multi-band Magnetoencephalogram Study Of Migraine Patients After Somatosensory Stimulation

Objective:The present study aimed to investigate the abnormalities of the frequency-specific somatosensory-related network in migraine patients during headache-free phase by using MEGMethods:Twenty-two migraineurs in the interictal phase and twenty-two sex-and age-matched healthy volunteers were studied using a whole-head magnetoencephalography(MEG)system.Electrical stimuli were delivered alternately to the median nerve on the right wrists of all subj ects.MEG data were analyzed in a frequency range of 1-1000 Hz in multiple bandsResults:The brain network patterns revealed that the patients with migraine exhibited remarkably increased functional connectivity in the high-frequency(250-1000 Hz)band between the sensory cortex and the frontal lobe.The results of quantitative analysis of graph theory showed that the patients had(1)an increased degree of connectivity in the theta(4-8 Hz),beta(13-30 Hz)and gamma(30-80 Hz)bands;(2)an increased connectivity strength in the beta(13-30 Hz)and gamma(30-80 Hz)bands;(3)an increased path length in the beta(13-30 Hz),gamma(30-80 Hz)and ripple(80-250 Hz)bands;and(4)an increased clustering coefficient in the theta(4-8 Hz),beta(13-30 Hz)and gamma(30-80 Hz)bandsConclusions:The results indicate that functional connectivity of somatosensory related brain network in migraine patients during ictal phase is significantly elevated and is frequency dependObjective:To explore the spectrum power of sensory-related regions of migraineur under somatosensory stimulation in multi-frequency bandMethods:Twenty-two migraine patients without aura in the interictal phase and twenty-eight age-ang gender-matched healthy volunteers were enrolled.The brain magnetoencephalography(MEG)signal evoked by median never stimulation was collected.The difference of spectrum power under electrical somatosensory stimulation in different brain regions between migraine group and control group were compared through time-frequency analysis.Results:After left wrist stimulation,the power value of contralateral anterior cingulate cortex(ACC),amygdala,periaqueductal gray(PAG)were significantly reduced;while the power value of contralateral primary sensory cortex were significantly increased in the alpha band.After right wrist stimulation,the spectrum power of contralateral PAG were significantly decreased in the beta and HFO band The power value of right dorsal-lateral prefrontal cortex(DLPFC)with migraine was positively correlated with MIDAS scores in the alpha band.The power value of left thalamus with migraine were negatively correlated with headache frequencyConclusion:This result indicates migraine patients show abnormal brain excitability under somatosensory stimulation and may contribute to the clinical characteristic of this disorder.