A Clinical Study Of Xiaofeng Powder In The Treatment Of Non-small Cell Lung Cancer EGFR-TKI-related Damp-heat Rash

Objective:To observe the clinical efficacy of Xiaofengsan in treating EGFR-TKI associated damp-heat rash in non-small cell lung cancer.Methods:Sixty patients who met the inclusion criteria were divided into two groups according to the principle of randomized control.Among them,30 patients in the treatment group(Zhufeng Powder plus oral and external washing),and 30 patients in the control group(Minocycline hydrochloride capsules orally combined with Red mold)Ointment for external use).After continuous observation for 14 days,the two groups of patients used the same method for symptomatic treatment during the treatment,and compared the syndrome score,rash relief rate,rash first relief time,quality of life evaluation(KPS score),peripheral blood inflammation.Factors such as factor level,adverse reactions and safety were observed to observe the clinical efficacy of the two groups.Statistical analysis was performed using statistical SPSS 17.0.Result: 1.Comparison of rash remission rate: After treatment,the rash grades of the two groups were lower than before,and the difference was statistically significant(P<0.05).2.Comparison of the first remission time of rash:Via Wilcoxon rank sum test,?=-3.267,P=0.001<0.01,the difference was statistically significant.3.Comparison of TCM syndrome scores between the two groups:TCM syndrome scores of the two groups were improved after treatment,and the difference was statistically significant(P<0.01).4.Comparison of quality of life between the two groups:After treatment,the KPS scores of the two groups were increased,the difference was statistically significant(P=0.018<0.05).5.Peripheral blood inflammatory factors high-sensitivity C-reactive protein(CRP),interleukin-6(IL-6)comparison: after treatment,the levels of peripheral blood inflammatory factors decreased in the two groups(P=0.028<0.05,P=0.033< 0.05).6.Comparison of adverse reactions and safety: There was no significant difference in safety between the two groups,and no significant adverse reactions and side effects were observed.Conclusion: 1.Xiaofengsan flavor oral and external washing has obvious curative effect on EGFR-TKI-associated damp-heat type rash,and it is superior to minocycline hydrochloride capsule orally combined with erythromycin ointment for external treatment.2.Xiaofengsan flavor oral and external washing treatment patients with rash first time to relapse earlier than the minocycline hydrochloride capsules orally with erythromycin ointment topical group.3.Xiaofengsan flavor oral and external washing can improve the patient's KPS score.4.Xiaofengsan flavor oral and external washing can reduce the level of peripheral blood inflammatory factors in patients.5.Xiaofeng Sanwei oral and external washing safety is good,no adverse reactions occur.