Screening And Application Research On Core Items Of Hepatitis C Prevention Knowledge Among Drug Users

ObjectivesTo provide a convinent evaluation tool and scientific evidence for health education work on hepatitis C among people who inject drugs(PWID),this study is designed to screen core items of investigation questionnaire on HCV prevention knowledge awareness among PWID,assess reliability and validity of the questionnaire and investigate HCV knowledge awareness among attendants in methadone maintenance treatment(MMT)clinics in Yunnan Province,and find out its influence factors.MethodsInvestigation questionnaire on HCV prevention knowledge awareness among PWID was developed and based on it,expert consultation questionnaires for Delphi investigation were designed.To screen the core items,the expert consultation questionnaires were distributed to 30 experts engaged in interventions on PWID,HCV prevention or HCV treatment for 2 rounds using Delphi technique and the consultation results were analyzed.Meanwhile,to know about the demography characteristics,behaviors related to drug use and HCV prevention knowledge awareness among PWID,unified electronic investigation questionnaire on HCV prevention knowledge awareness was used among the enrolled 410 patients of 4 MMT clinics from 4 different counties in Yunnan Province,followed by face-to-face interviews.Furthermore,the reliability of investigation questionnaire on HCV prevention knowledge awareness was assessed with Cronbach a coefficient and Guttman Split-Half coefficient,and the validity of the questionnaire was evaluated with exploratory and conformatory factor analysis by SPSS21.0 and AMOS21.0.ResultsThe investigation questionnaire on HCV prevention knowledge among PWID included 22 items related to HCV prevention konwledge and 3 items about utilization of HCV service,and among these 22 items,5 items were deleted in first round,9 items were deleted in second round and finally 8 items were remained as the core items by Delphi technique.During the Delphi investigation,the valid response rates of expert consultation in 2 rounds were both 100%;the coefficient of the experts'authorities Cr was 0.932±0.069;the Kendall's concordance coefficient of 2 rounds were 0.207 and 0.487 separately(both P<0.05).Through investigation on HCV prevention knowledge awareness among PWID inMMT clinics,a total of 398 valid questionnaires were collected.HCV awareness among attendants in MMT clinics in Yunnan Province was 79.9%;among 22 questions.the correction rate for answering each question varied from 53.0%to 94.2%,and mean score was 17.6±4.1;the awareness of HCV treatment and mother-to-child transmission knowledge were relatively low,with the correction rate of<60%and 68.5%,respectively;multi-factor analysis among surveyed respondents showed that factors as:receiving HCV information,education and communication(IEC)(OR=9.82,95%CI:5.19?18.57),employed status(OR=0,29,95%CI:0.16?0.55),lower educational level(illiteracy:0.12.95%CI:0.03?0.55;primary school education:OR=0.30,95%CI:0.10?0.91)and therapy period lower than 5 years of receiving MTT treatment(OR=0.34,95%Cl:0.15?0.77)were primarily associated with HCV awareness.respectively(P<0.05).For investigation questionnaire on HCV knowledge awareness among PWID,the Cronbach a coefficient and Guttman Split-Half coefficient were 0.857 and 0.840,respectively;5 factors were obtained from exploartory factor analysis;confirmatory factor analysis showed the final model was suitable for data and its core fit summary were as follows:?2/DF=1.717<2,RMSEA=0.060<0.080,GFI=0.865>0.850,and CFI=0.867.ConclusionsIn this study,the 8 core items of HCV prevention knowledge of PWID chosen through Delphi method have better professional representative and can be used to reflect HCV awareness among PWID.so it is suggested to use these items as key evaluation indicators:investigation questionnaire on HCV knowledge awareness among PWID is effective and valid for measuring the HCV awareness status among PWID;HCV knowledge awareness is relatively high among attendants in MMT clinics in Yunnan Province;in future,HCV knowledge on treatment and mother to child transmission should be strengthened among PWID and those of the employed and with lower educational background should be paid attention in particular.